Department of Health Sciences, Division of Geriatric Medicine, Lund University, Malmö University Hospital, Malmö, Sweden.
Int J Gen Med. 2009 Dec 29;2:145-51. doi: 10.2147/ijgm.s5907.
ST segment depression (STDE) has been found to be associated with cardiovascular disease in the elderly. Studies of the relation of ambulatory STDE to cognitive function in elderly persons aged 80 years or above is lacking.
To study the association between STDE and cognition.
A cross-sectional cohort study of 88 81-year-old men from the population study "Men born in 1914" investigated in an outpatient research clinic. Measurements included ambulatory 24-hour electrocardiogram (ECG) monitoring and a cognitive test battery of six tests. Proportion of lower cognitive function was calculated for each test in relation to STDE during the day and at night-time.
Fifty-eight percent of the men had STDE and a higher proportion with low visuospatial cognitive function was found among those with STDE compared to the others (84% vs 59%; p = 0.014). A significant trend was noted for subjects without STDE compared to STDE night-time less than 60 minutes and night-time more than 60 minutes for spatial and verbal cognitive functions (p = 0.022). No trends were noted for STDE daytime. Maximal STDE during night showed similar association to spatial function (Benton Visual Retention test, r = -0.26; p = 0.028). Even when seven subjects with a history of stroke were excluded, the occurrence of STDE was associated to lower visuospatial cognitive function compared to those without STDE (87% vs 57%; p = 0.004).
ST segment depression on ECG is common among elderly men and might be a vascular risk factor for cognitive deterioration.
研究 ST 段压低与认知功能的关系。
这是一项横断面队列研究，研究对象为参加门诊研究诊所检查的 88 名 81 岁男性。这些男性来自于“1914 年出生男性”的人群研究。研究测量包括 24 小时动态心电图（ECG）监测和 6 项认知测试的测试。根据日间和夜间 ST 段压低情况，计算每个测试的认知功能较低的比例。
58%的男性存在 ST 段压低，与无 ST 段压低的男性相比，存在 ST 段压低的男性低视觉空间认知功能的比例更高（84% vs 59%；p = 0.014）。与无 ST 段压低相比，ST 段压低夜间<60 分钟和夜间>60 分钟的受试者，在空间和语言认知功能方面存在显著趋势（p = 0.022）。日间 ST 段压低无此趋势。夜间最大 ST 段压低与空间功能也有类似的关联（Benton 视觉保持测试，r = -0.26；p = 0.028）。即使排除 7 名有中风病史的患者，ST 段压低的发生与无 ST 段压低的患者相比，与较低的视觉空间认知功能相关（87% vs 57%；p = 0.004）。
心电图上的 ST 段压低在老年男性中很常见，可能是认知功能恶化的血管危险因素。
