Department of Medicine and Microbiology, University of California, 513 Parnassus Ave., San Francisco, CA 91413, USA.
J Clin Invest. 2010 Apr;120(4):939-49. doi: 10.1172/JCI40567. Epub 2010 Apr 1.
The linkage of Kaposi sarcoma (KS) to infection by a novel human herpesvirus (Kaposi sarcoma-associated herpesvirus [KSHV]) is one of the great successes of contemporary biomedical research and was achieved by using advanced genomic technologies in a manner informed by a nuanced understanding of epidemiology and clinical investigation. Ongoing efforts to understand the molecular mechanisms by which KSHV infection predisposes to KS continue to be powerfully influenced by insights emanating from the clinic. Here, recent developments in KS pathogenesis are reviewed, with particular emphasis on clinical, pathologic, and molecular observations that highlight the many differences between this process and tumorigenesis by other oncogenic viruses.
卡波西肉瘤（KS）与一种新型人类疱疹病毒（卡波西肉瘤相关疱疹病毒[KSHV]）感染的关联是当代生物医学研究的重大成就之一，它是通过使用先进的基因组技术，并结合对流行病学和临床研究的细致理解来实现的。目前，人们正在努力了解 KSHV 感染导致 KS 的分子机制，这些研究仍然深受临床研究结果的影响。本文综述了 KS 发病机制的最新进展，特别强调了临床、病理和分子观察结果，这些结果突出了该过程与其他致癌病毒引发肿瘤的许多不同之处。
