Li Shasha, Bai Lei, Dong Jiazhen, Sun Rui, Lan Ke
State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, 430072, People's Republic of China.
Key Laboratory of Molecular Virology and Immunology, Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200031, People's Republic of China.
Adv Exp Med Biol. 2017;1018:91-127. doi: 10.1007/978-981-10-5765-6_7.
Kaposi's sarcoma-associated herpesvirus (KSHV), also known as Human herpesvirus 8 (HHV-8), is a member of the lymphotropic gammaherpesvirus subfamily and a human oncogenic virus. Since its discovery in AIDS-associated KS tissues by Drs. Yuan Chang and Patrick Moore, much progress has been made in the past two decades. There are four types of KS including classic KS, endemic KS, immunosuppressive therapy-related KS, and AIDS-associated KS. In addition to KS, KSHV is also involved in the development of primary effusion lymphoma (PEL) and certain types of multicentric Castleman's disease. KSHV manipulates numerous viral proteins to promote the progression of angiogenesis and tumorigenesis. In this chapter, we review the epidemiology and molecular biology of KSHV and the mechanisms underlying KSHV-induced diseases.
卡波西肉瘤相关疱疹病毒（KSHV），也称为人类疱疹病毒8型（HHV - 8），是嗜淋巴细胞性γ疱疹病毒亚科的成员，也是一种人类致癌病毒。自袁畅博士和帕特里克·摩尔博士在与艾滋病相关的卡波西肉瘤组织中发现该病毒以来，在过去二十年里取得了很大进展。卡波西肉瘤有四种类型，包括经典型卡波西肉瘤、地方性卡波西肉瘤、免疫抑制治疗相关型卡波西肉瘤和艾滋病相关型卡波西肉瘤。除了卡波西肉瘤外，KSHV还与原发性渗出性淋巴瘤（PEL）和某些类型的多中心Castleman病的发生发展有关。KSHV通过操纵多种病毒蛋白来促进血管生成和肿瘤发生的进程。在本章中，我们将综述KSHV的流行病学、分子生物学以及KSHV诱导疾病的潜在机制。
