Liu Baohua, Liu Aiping, Uchiyama Shigeto, Ueno Tomomi, Li Xuetuo, Wang Peiyu
Department of Social Medicine & Health Education, School of Public Health, Peking University, Beijing 100191, China.
Wei Sheng Yan Jiu. 2010 Jan;39(1):59-64.
To investigate the prevalence of equol producers and the physiological range of urinary equol excretion, and also to evaluate relations between equol phenotype and lifestyle among Chinese adults in Beijing.
100 male and 100 female adults participated in a cross-sectional study and provided twice 1d urine samples on regular diet and after 3d soy isoflavone challenge respectively. A health and demographics questionnaire, and 2d food record were completed before the urine collections. Isoflavones and their metabolites in urine were measured to determine equol phenotype by HPLC.
The physiological range of 24h urinary equol excretion was 0-76.56 micromol/24h, and the percentage of the equol producer phenotype was 26.8% on regular diet and 60.4% after soy isofavone challenge, respectively. There was no indication that habitual consumption of soy foods is associated with the equol producer phenotype. The correlations of isoflavone intake from 2d food record with those from urinary isoflavone levels were 0.58 for total isoflavones, 0.49 for daidzein, 0.56 for genistein, and 0.50 for glycitein (P < 0.01).
About one fourth of Chinese adults in Beijing were detected equol excretion in urine under the usually lifestyle. However, equol_producing potential was higher.
调查雌马酚生成者的比例以及尿中雌马酚排泄的生理范围，并评估北京成年中国人中雌马酚表型与生活方式之间的关系。
100名成年男性和100名成年女性参与了一项横断面研究，分别在正常饮食和3天大豆异黄酮激发后提供了两次24小时尿液样本。在收集尿液之前完成了一份健康和人口统计学调查问卷以及2天的食物记录。通过高效液相色谱法测定尿液中的异黄酮及其代谢产物以确定雌马酚表型。
24小时尿中雌马酚排泄的生理范围为0 - 76.56微摩尔/24小时，正常饮食时雌马酚生成者表型的比例分别为26.8%，大豆异黄酮激发后为60.4%。没有迹象表明习惯性食用大豆食品与雌马酚生成者表型有关。从2天食物记录中得出的异黄酮摄入量与尿中异黄酮水平的相关性，总异黄酮为0.58，黄豆苷元为0.49，染料木黄酮为0.56，大豆黄素为0.50（P < 0.01）。
在北京的成年中国人中，约四分之一在通常生活方式下尿中检测到雌马酚排泄。然而，生成雌马酚的潜力更高。
