Faculty of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, People's Republic of China.
Br J Nutr. 2012 Nov 14;108(9):1698-704. doi: 10.1017/S0007114511007331. Epub 2012 Feb 29.
Previous studies have suggested that the daidzein metabolite equol rather than daidzein itself contributes to the beneficial effect of soya foods in the prevention of CVD. The aim of the present study is to examine the proportion of equol excretion in Chinese adults and compare plasma lipids and carotid artery intima-media thickness (IMT) between equol excretors and non-excretors, and to evaluate the effect of soya isoflavone intakes on serum lipids and IMT in either equol excretors or non-excretors. Subjects (n 572; women n 362, men n 210) were recruited for the present study. An overnight urine sample was provided by each subject on their usual diet to quantify urinary concentrations of daidzein and equol. Far-wall IMT was determined by B-mode ultrasound in the right carotid at two sites, carotid bulb (CB-IMT) and common carotid artery (CCA-IMT), and fasting serum lipids were measured. Habitual dietary intakes were estimated with a FFQ, and soya isoflavone intake derived from the FFQ was assessed. Of the 572 subjects, the proportion of equol excretors on their usual diet was 25·0 % (n 143). Compared with non-excretors, equol excretors showed significantly lower serum TAG (-38·2 (95 % CI -70·4, -5·9) %, P = 0·012) and CCA-IMT (-4·9 (95 % CI -9·7, -0·3) %, P = 0·033). Equol excretors with higher daily isoflavone intakes (-5·4 mg/d) had significantly lower IMT (-16·2 %, P = 0·035) and tended to have higher HDL-cholesterol (P = 0·055) than did those with lower daily isoflavone intakes (1·5 mg/d), while no association was observed between soya isoflavone intakes and serum lipids or IMT in non-excretors. In conclusion, the benefits of soya isoflavones in preventing CVD may be apparent among equol excretors only.
先前的研究表明，染料木黄酮的代谢产物黄豆黄素而非染料木黄酮本身有助于大豆食品预防心血管疾病的有益作用。本研究的目的是检验中国成年人黄豆黄素代谢产物黄豆黄素的排泄比例，并比较黄豆黄素排泄者和非排泄者的血浆脂质和颈动脉内膜中层厚度（IMT），同时评估大豆异黄酮的摄入量对排泄者或非排泄者的血清脂质和 IMT 的影响。研究对象（n=572；女性 n=362，男性 n=210）被招募参加本研究。每位研究对象在正常饮食下提供了一整夜的尿液样本，以定量尿液中染料木黄酮和黄豆黄素的浓度。通过右颈动脉的 B 模式超声在两个部位（颈动脉球部[CB-IMT]和颈总动脉[CCA-IMT]）测量远壁 IMT，并测量空腹血清脂质。通过 FFQ 估计习惯性饮食摄入量，并评估 FFQ 中得出的大豆异黄酮摄入量。在 572 名研究对象中，正常饮食下黄豆黄素排泄者的比例为 25.0%（n=143）。与非排泄者相比，黄豆黄素排泄者的血清 TAG 明显更低（-38.2（95%CI-70.4，-5.9）%，P=0.012），CCA-IMT 也更低（-4.9（95%CI-9.7，-0.3）%，P=0.033）。每日摄入更多大豆异黄酮（-5.4mg/d）的黄豆黄素排泄者，IMT 明显更低（-16.2%，P=0.035），且 HDL-胆固醇有升高趋势（P=0.055），而每日摄入较低大豆异黄酮（1.5mg/d）的排泄者则无此关联。在非排泄者中，大豆异黄酮的摄入量与血清脂质或 IMT 之间没有观察到相关性。综上所述，大豆异黄酮预防心血管疾病的益处可能仅在黄豆黄素排泄者中表现明显。
