Makhdoom Asadullah, Khan Muhammad Shoaib, Lagahari Muhammad Ayub, Rahopoto Muhammad Qasim, Tahir Syed Muhammad, Siddiqui Khaleeque Ahmad
Department of Orthopaedic Surgery & Traumatology, Liaquat University of Medical & Health Sciences, Jamshoro Sindh, Pakistan.
J Ayub Med Coll Abbottabad. 2009 Jan-Mar;21(1):103-5.
Many studies have demonstrated that honey has antibacterial activity in vitro, and a small number of clinical case studies have shown that application of honey to severely infected cutaneous wounds is capable of clearing infection from the wound and improving tissue healing. Research has also indicated that honey may possess anti-inflammatory activity and stimulate immune responses within a wound. The overall effect is to reduce infection and to enhance wound healing in burns, ulcers, and other cutaneous wounds. The objective of the study was to find out the results of topical wound dressings in diabetic wounds with natural honey.
The study was conducted at department of Orthopaedics, Unit-1, Liaquat University of Medical and Health Sciences, Jamshoro from July 2006 to June 2007. Study design was experimental. The inclusion criteria were patients of either gender with any age group having diabetic foot Wagner type I, II, III and II. The exclusion criteria were patients not willing for studies and who needed urgent amputation due to deteriorating illness. Initially all wounds were washed thoroughly and necrotic tissues removed and dressings with honey were applied and continued up to healing of wounds.
Total number of patients was 12 (14 feet). There were 8 males (66.67%) and 4 females (33.33%), 2 cases (16.67%) were presented with bilateral diabetic feet. The age range was 35 to 65 years (46 +/- 9.07 years). Amputations of big toe in 3 patients (25%), second and third toe ray in 2 patients (16.67%) and of fourth and fifth toes at the level of metatarsophalengeal joints were done in 3 patients (25%). One patient (8.33%) had below knee amputation.
In our study we observed excellent results in treating diabetic wounds with dressings soaked with natural honey. The disability of diabetic foot patients was minimized by decreasing the rate of leg or foot amputations and thus enhancing the quality and productivity of individual life.
许多研究已证明蜂蜜在体外具有抗菌活性,少数临床病例研究表明,将蜂蜜应用于严重感染的皮肤伤口能够清除伤口感染并促进组织愈合。研究还表明,蜂蜜可能具有抗炎活性并刺激伤口内的免疫反应。总体效果是减少烧伤、溃疡和其他皮肤伤口的感染并促进伤口愈合。该研究的目的是了解天然蜂蜜用于糖尿病伤口局部伤口敷料的效果。
该研究于2006年7月至2007年6月在詹姆肖罗利亚卡特医学与健康科学大学第一单元骨科进行。研究设计为实验性。纳入标准为任何年龄组的糖尿病足瓦格纳I型、II型、III型和II型的男女患者。排除标准为不愿意参加研究以及因病情恶化需要紧急截肢的患者。最初,所有伤口均彻底清洗,清除坏死组织,然后用蜂蜜敷料进行处理,直至伤口愈合。
患者总数为12例(14只脚)。男性8例(66.67%),女性4例(33.33%),2例(16.67%)为双侧糖尿病足。年龄范围为35至65岁(46±9.07岁)。3例患者(25%)的大脚趾截肢,2例患者(16.67%)的第二和第三趾列截肢,3例患者(25%)在跖趾关节水平的第四和第五趾截肢。1例患者(8.33%)进行了膝下截肢。
在我们的研究中,我们观察到用天然蜂蜜浸泡的敷料治疗糖尿病伤口取得了优异的效果。通过降低腿部或足部截肢率,将糖尿病足患者的残疾程度降至最低,从而提高个人生活质量和生产力。