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正常和癫痫脑网络中背景活动的功能模块化。

Functional modularity of background activities in normal and epileptic brain networks.

机构信息

CNRS UMR-7225, Hôpital de la Salpêtrière, 47 Boulevard de l'Hôpital, 75013 Paris, France.

出版信息

Phys Rev Lett. 2010 Mar 19;104(11):118701. doi: 10.1103/PhysRevLett.104.118701. Epub 2010 Mar 18.

Abstract

We analyze the connectivity structure of weighted brain networks extracted from spontaneous magnetoencephalographic signals of healthy subjects and epileptic patients (suffering from absence seizures) recorded at rest. We find that, for the activities in the 5-14 Hz range, healthy brains exhibit a sparse connectivity, whereas the brain networks of patients display a rich connectivity with a clear modular structure. Our results suggest that modularity plays a key role in the functional organization of brain areas during normal and pathological neural activities at rest.

摘要

我们分析了从健康受试者和记录在休息状态下的癫痫患者(患有失神发作)的自发脑磁图信号中提取的加权脑网络的连接结构。我们发现,对于 5-14 Hz 范围内的活动,健康大脑表现出稀疏的连接性,而患者的大脑网络显示出丰富的连接性和明显的模块结构。我们的结果表明,模块性在正常和病理神经活动期间大脑区域的功能组织中起着关键作用。

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