代谢综合征在银屑病关节炎患者中的患病率增加。
Increased prevalence of the metabolic syndrome in patients with psoriatic arthritis.
机构信息
VA Medical Center, Mather, California, USA.
出版信息
Metab Syndr Relat Disord. 2010 Aug;8(4):331-4. doi: 10.1089/met.2009.0124.
OBJECTIVES
Psoriasis (PsO) is a common chronic T cell-mediated inflammatory disorder traditionally thought to manifest in the skin and joints (psoriatic arthritis, PsA). Recently, it has been shown that these patients have an increased risk for myocardial infarction and this was greater with increasing severity of psoriasis. Patients with psoriasis have reported to have cardiometabolic disturbances including obesity, insulin resistance, and dyslipidemia. This constellation of risk factors, referred to as the metabolic syndrome, increases the risk for atherosclerotic cardiovascular disease (ASCVD) and type 2 diabetes mellitus. The aim of this study was to determine the prevalence of metabolic syndrome in PsA.
METHODS
In our study, we examined the records of 105 patients with PsA to determine the prevalence of metabolic syndrome in PsA. This was a retrospective analysis of the Sacramento Veterans Affairs database.
RESULTS
Our results demonstrated an increased prevalence of the metabolic syndrome in patients with PsA (61/105 patients or 58.1%) compared to the 35.2 % reported for the Third National Health and Nutrition Examination Survery (NHANES III) data.
CONCLUSIONS
Thus, patients with PsA have a very high prevalence of metabolic syndrome, which predisposes them to an increased risk of both diabetes and ASCVD.
目的
银屑病（PsO）是一种常见的慢性 T 细胞介导的炎症性疾病，传统上认为它会在皮肤和关节（银屑病关节炎，PsA）中表现出来。最近，已经表明这些患者患心肌梗死的风险增加，并且随着银屑病的严重程度增加而增加。银屑病患者报告存在代谢紊乱，包括肥胖、胰岛素抵抗和血脂异常。这种危险因素的组合，称为代谢综合征，增加了动脉粥样硬化性心血管疾病（ASCVD）和 2 型糖尿病的风险。本研究的目的是确定 PsA 中代谢综合征的患病率。
方法
在我们的研究中，我们检查了 105 例 PsA 患者的记录，以确定 PsA 中代谢综合征的患病率。这是对萨克拉门托退伍军人事务数据库的回顾性分析。
结果
我们的结果表明，与第三次全国健康和营养检查调查（NHANES III）数据报告的 35.2%相比，PsA 患者中代谢综合征的患病率增加（105 例患者中有 61 例或 58.1%）。
结论
因此，患有 PsA 的患者代谢综合征的患病率非常高，这使他们患糖尿病和 ASCVD 的风险增加。
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