肿瘤抑制因子程序性细胞死亡蛋白4（PDCD4）及其拮抗物致癌性微小RNA-21（miR-21）是否失控了？
Have tumor suppressor PDCD4 and its counteragent oncogenic miR-21 gone rogue?
作者信息
Young Matthew R, Santhanam Arti N, Yoshikawa Noriko, Colburn Nancy H
机构信息
Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, Frederick, MD, 21702, USA.
出版信息
Mol Interv. 2010 Apr;10(2):76-9. doi: 10.1124/mi.10.2.5.
Abstract
A recent article suggests that the well known tumor suppressor PDCD4 also functions as a pro-inflammatory agent. The PDCD4 counteragent miR-21, a pro-oncogenic micro-RNA, is described as an anti-inflammatory agent. The authors of this research article provide evidence that mice lacking PDCD4 are protected from the lethal effects of lipopolysaccharide (LPS). This report also confirms miR-21 as a negative regulator of PDCD4 expression after LPS stimulation. Downstream mediators of the pro-inflammatory activity of PDCD4 include IL-10, an anti-inflammatory cytokine that is negatively regulated by PDCD4, and IL-6, a pro-inflammatory cytokine that appears to be upregulated in a PDCD4 dependent manner, possibly through an increase in NF-κB activity. Is it possible that a tumor-suppressor protein and an oncogenic micro-RNA can be oppositely targeted to control inflammatory disease?
摘要
最近一篇文章表明，著名的肿瘤抑制因子PDCD4也具有促炎因子的功能。PDCD4的拮抗物miR-21是一种促癌微小RNA，被描述为一种抗炎因子。这篇研究文章的作者提供证据表明，缺乏PDCD4的小鼠可免受脂多糖（LPS）的致死作用。该报告还证实，miR-21是LPS刺激后PDCD4表达的负调节因子。PDCD4促炎活性的下游介质包括IL-10（一种抗炎细胞因子，受PDCD4负调节）和IL-6（一种促炎细胞因子，似乎以PDCD4依赖的方式上调，可能是通过NF-κB活性的增加）。一种肿瘤抑制蛋白和一种致癌微小RNA有可能被反向靶向以控制炎症性疾病吗？
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本文引用的文献
1
Pdcd4 repression of lysyl oxidase inhibits hypoxia-induced breast cancer cell invasion.Pdcd4 通过抑制赖氨酰氧化酶抑制低氧诱导的乳腺癌细胞侵袭。
Oncogene. 2010 Jul 8;29(27):3921-32. doi: 10.1038/onc.2010.158. Epub 2010 May 24.
2
Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21.通过 microRNA miR-21 靶向促炎肿瘤抑制因子 PDCD4 对 TLR4 进行负调控。
Nat Immunol. 2010 Feb;11(2):141-7. doi: 10.1038/ni.1828. Epub 2009 Nov 29.
3
Development of a high-throughput cell-based reporter assay to identify stabilizers of tumor suppressor Pdcd4.开发一种基于细胞的高通量报告基因检测方法以鉴定肿瘤抑制因子Pdcd4的稳定剂。
J Biomol Screen. 2010 Jan;15(1):21-9. doi: 10.1177/1087057109351028. Epub 2009 Nov 9.
4
Pdcd4, a colon cancer prognostic that is regulated by a microRNA.Pdcd4，一个受 microRNA 调控的结肠癌预后标志物。
Crit Rev Oncol Hematol. 2010 Mar;73(3):185-91. doi: 10.1016/j.critrevonc.2009.09.001. Epub 2009 Dec 22.
5
MicroRNAs in Cancer.癌症中的微小RNA
Annu Rev Med. 2009;60:167-79. doi: 10.1146/annurev.med.59.053006.104707.
6
The tumour suppressor Pdcd4: recent advances in the elucidation of function and regulation.肿瘤抑制因子Pdcd4：功能与调控机制解析的最新进展
Biol Cell. 2009 Jun;101(6):309-17. doi: 10.1042/BC20080191.
7
MicroRNA-21 protects against the H(2)O(2)-induced injury on cardiac myocytes via its target gene PDCD4.MicroRNA-21 通过其靶基因 PDCD4 对心肌细胞的 H(2)O(2)诱导损伤起保护作用。
J Mol Cell Cardiol. 2009 Jul;47(1):5-14. doi: 10.1016/j.yjmcc.2009.01.008. Epub 2009 Jan 27.
8
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J Cell Mol Med. 2009 Jan;13(1):39-53. doi: 10.1111/j.1582-4934.2008.00556.x.
9
An autoregulatory loop mediated by miR-21 and PDCD4 controls the AP-1 activity in RAS transformation.由miR-21和PDCD4介导的自调节环控制RAS转化中的AP-1活性。
Oncogene. 2009 Jan 8;28(1):73-84. doi: 10.1038/onc.2008.370. Epub 2008 Oct 13.
10
MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene.微小RNA-21通过靶向程序性细胞死亡4基因促进细胞转化。
Oncogene. 2008 Jul 17;27(31):4373-9. doi: 10.1038/onc.2008.72. Epub 2008 Mar 31.
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