Sun Qing-Zeng, Guan Tong-Yu, Qi Jing-Guang, Cao Jing-Yi, Wu Gang, Yang Ning, Cheng Zheng-Yu, Liang Jie, Wang Qian
Jiangsu University School of Clinical Medicine, Zhenjiang, Jiangsu 212013, China.
Zhonghua Nan Ke Xue. 2010 Feb;16(2):118-22.
To investigate the pathohistological characteristics of the prostate tissues in patients who receive a second TURP and to evaluate their clinical significance.
We collected surgical specimens from 50 cases of TURP (the control group) and another 50 cases of re-TURP (the re-TURP group), detected the expressions of CD34, vascular endothelial growth factor (VEGF) and androgen receptor (AR) in the prostate tissues by immunohistochemistry (S-P), and determined microvessel density (MVD) and the expressions of VEGF and AR. We performed statistical analyses on the results obtained from the specimens of the control group as well as from those of the first and second operations of the re-TURP group.
VEGF and AR expressed in all the specimens. The expressions of VEGF and AR and MVD were significantly higher in the re-TURP group than in the controls (P < 0.05), but showed no significant differences between the first and second operations in the re-TURP group (P > 0.05). Positive correlations were found between the expressions of AR and VEGF, VEGF and MVD, and AR and MVD (r = 0.650, 0.705 and 0.525, P < 0.05).
Increased AR, VEGF and MVD in the prostatic tissues may be one of the important causes of recurrence of BPH after TURP, and could be considered as the risk factors for postoperative recurrence and targeted indicators for preventive measures.
探讨接受二次经尿道前列腺电切术（TURP）患者前列腺组织的病理组织学特征，并评估其临床意义。
收集50例TURP患者的手术标本（对照组）和另外50例再次TURP患者的手术标本（再次TURP组），采用免疫组织化学（S-P法）检测前列腺组织中CD34、血管内皮生长因子（VEGF）和雄激素受体（AR）的表达，并测定微血管密度（MVD）以及VEGF和AR的表达。对对照组标本以及再次TURP组首次和二次手术标本的结果进行统计学分析。
所有标本中均有VEGF和AR表达。再次TURP组VEGF和AR的表达及MVD均显著高于对照组（P < 0.05），但再次TURP组首次和二次手术之间差异无统计学意义（P > 0.05）。AR与VEGF的表达、VEGF与MVD以及AR与MVD之间均呈正相关（r = 0.650、0.705和0.525，P < 0.05）。
前列腺组织中AR、VEGF和MVD升高可能是TURP术后良性前列腺增生（BPH）复发的重要原因之一，可作为术后复发的危险因素及预防措施的靶向指标。
