Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, Beijing 100034, China.
Chin Med J (Engl). 2010 May 5;123(9):1154-7.
Both benign prostatic hyperplasia (BPH) and primary hypertension are common in the elderly men. The purpose of this study was to investigate the possible effect of primary hypertension on the hematuria in patients with BPH.
All patients who underwent transurethral resection of prostate or opening operation had confirmed diagnoses of BPH histologically. comparative analysis of packet was used to analyze the incidence of hematuria in 423 BPH patients with or without hypertension. Immunostaining of CD34 and vascular endothelial growth factor (VEGF) was carried out in tissues of 50 cases of simple BPH and 50 cases of BPH accompanied with hypertension.
The incidence of hematuria in the BPH with hypertension was significantly higher than that in the simple BPH (P < 0.01). Furthermore, the incidence of hematuria in patients who had hypertension for more than 10 years was clearly higher than that in the patients who had hypertension for less than 10 years (P < 0.01). Both microvessel density (MVD) based on CD34 immunostaining and VEGF expression were significantly higher in the BPH tissues of patients with hypertension than that in the simple BPH (P < 0.01, P < 0.05).
Long-term hypertension may significantly increase the incidence of hematuria in patients with both BPH and hypertension. Increased MVD level and VEGF expression may account for the higher incidence of hematuria in these patients.
良性前列腺增生症（BPH）和原发性高血压在老年男性中都很常见。本研究旨在探讨原发性高血压对 BPH 患者血尿的可能影响。
所有接受经尿道前列腺切除术或开放手术的患者均经组织学证实患有 BPH。采用分组比较分析方法，分析了 423 例伴或不伴高血压的 BPH 患者血尿的发生率。对 50 例单纯 BPH 组织和 50 例伴高血压的 BPH 组织进行 CD34 和血管内皮生长因子（VEGF）免疫染色。
高血压 BPH 患者血尿发生率明显高于单纯 BPH（P<0.01）。此外，高血压病史>10 年的患者血尿发生率明显高于<10 年的患者（P<0.01）。高血压 BPH 组织中 CD34 免疫染色的微血管密度（MVD）和 VEGF 表达均明显高于单纯 BPH（P<0.01，P<0.05）。
长期高血压可能会显著增加 BPH 合并高血压患者血尿的发生率。MVD 水平升高和 VEGF 表达增加可能是这些患者血尿发生率较高的原因。
