Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore.
J Org Chem. 2010 May 7;75(9):3002-6. doi: 10.1021/jo100254g.
An in situ generated catalyst from readily available RuH(2)(PPh(3))(4), an N-heterocyclic carbene (NHC) precursor, NaH, and acetonitrile was developed. The catalyst showed high activity for the amide synthesis directly from either alcohols or aldehydes with amines. When a mixture of an alcohol and an aldehyde was reacted with an amine, both of the corresponding amides were obtained with good yields. Homogeneous Ru(0) complexes such as (eta(4)-1,5-cyclooctadiene)(eta(6)-1,3,5-cyclooctatriene)ruthenium [Ru(cod)(cot)] and Ru(3)(CO)(12) were also active in the amidation of an alcohol or an aldehyde with the help of an in situ generated NHC ligand.
开发了一种由易得的 RuH(2)(PPh(3))(4)、N-杂环卡宾(NHC)前体、NaH 和乙腈原位生成的催化剂。该催化剂在胺直接从醇或醛合成酰胺方面表现出高活性。当醇和醛的混合物与胺反应时,都可以得到相应的酰胺,产率良好。均相 Ru(0)配合物,如(eta(4)-1,5-环辛二烯)(eta(6)-1,3,5-环辛三烯)钌[Ru(cod)(cot)]和 Ru(3)(CO)(12),在原位生成的 NHC 配体的帮助下,也能有效地使醇或醛进行酰胺化反应。