定义明确的 Cp*Ru 配合物在质子化胺配体存在下催化酰胺和酯的氢化反应。
Catalytic hydrogenation of carboxamides and esters by well-defined Cp*Ru complexes bearing a protic amine ligand.
机构信息
Department of Applied Chemistry, Graduate School of Science and Engineering, Tokyo Institute of Technology, 2-12-1 O-okayama, Meguro-ku, Tokyo 152-8552, Japan.
出版信息
J Am Chem Soc. 2011 Mar 30;133(12):4240-2. doi: 10.1021/ja1117254. Epub 2011 Mar 7.
PMID:21381768
Abstract
A novel catalytic method for the straightforward hydrogenation of carboxamides and esters to primary alcohols has been developed. Chiral modification in the ligand sphere of the well-defined Cp*Ru catalyst molecule opens up a new possibility for the development of an enantioselective hydrogenation of racemic substrates via dynamic kinetic resolution.
摘要
一种新颖的催化方法，可直接将酰胺和酯氢化为伯醇，已经被开发出来。在明确的 Cp*Ru 催化剂分子的配体场中进行手性修饰，为通过动力学拆分实现外消旋底物的对映选择性氢化开辟了新的可能性。
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