Rabotti G F, Gogusev J, Teutsch B, Mongiat-Lardemer F, Haguenau F
J Natl Cancer Inst. 1978 Jan;60(1):113-24. doi: 10.1093/jnci/60.1.113.
Cell lines from the brains of inbred CF hamster embryos were established in vitro. The morphology of the cells in the light and electron microscopes was that of glial cells, and the cells contained the nervous system-specific protein S-100. Infection with the Schmidt-Ruppin strain of Rous sarcoma virus, subgroup B, resulted in foci of transformation. The transformed cells were virogenic and upon intracerebral and sc inoculations into young hamsters, they developed into histologically typical gliomas.
从近交系CF仓鼠胚胎大脑中建立了细胞系并进行体外培养。这些细胞在光学显微镜和电子显微镜下的形态表现为神经胶质细胞，且细胞中含有神经系统特异性蛋白S - 100。用罗氏肉瘤病毒施密特-鲁平株B亚组感染这些细胞后，出现了转化灶。转化后的细胞具有病毒产生能力，将其脑内接种和皮下接种到幼龄仓鼠后，会发展成组织学上典型的胶质瘤。
