经多瘤病毒体外转化的仓鼠脑细胞致瘤克隆。超微结构和免疫组织化学研究。
Tumorigenic clones of hamster brain cells transformed in vitro by polyoma virus. Ultrastructural and immunohistochemical study.
作者信息
Tripier M F, Hassoun J, de Micco C, Meyer G, Toga M
出版信息
Acta Neuropathol. 1979 Dec;48(3):189-97. doi: 10.1007/BF00690519.
The morphological characteristics of three clones of hamster brain cells transformed in vitro by polyoma virus and of the tumors obtained after subcutaneous grafting of these cells in syngenic animals are reported. These clones appeared to be glial in nature by light and electron microscopy. The initial tumors induced by the three clones presented astrocytic features both by electron microscopy and immunohistochemistry. Analysis of the subsequent in vivo passages showed a decrease in cell differentiation, which was accompanied by a decrease in the latency period; after 2 years of serial transplantation, the tumors seemed poorly differentiated gliomas. A control cell line of hamster cerebellar cells evolved similarly.
报道了由多瘤病毒体外转化的三种仓鼠脑细胞克隆的形态学特征，以及将这些细胞皮下移植到同基因动物后所获得肿瘤的形态学特征。通过光学显微镜和电子显微镜观察，这些克隆在本质上似乎是神经胶质细胞。由这三种克隆诱导产生的初始肿瘤，在电子显微镜和免疫组织化学检查中均呈现星形细胞特征。对随后体内传代的分析显示细胞分化程度降低，同时潜伏期缩短；连续移植两年后，这些肿瘤似乎是低分化胶质瘤。仓鼠小脑细胞的对照细胞系也有类似的演变。
Zotero 插件