意大利患者人群中 HLA-B27 相关急性前葡萄膜炎的临床特征和预后。

Clinical features and prognosis of HLA B27-associated acute anterior uveitis in an Italian patient population.

机构信息

Department of Ophthalmology, Ocular Immunovirology Service, La Sapienza University of Rome, Rome, Italy.

出版信息

Ocul Immunol Inflamm. 2010 Apr;18(2):91-6. doi: 10.3109/09273941003597268.

DOI:10.3109/09273941003597268

PMID:20370333

Abstract

PURPOSE

To report clinical features and prognosis of HLA B27 acute anterior uveitis.

METHODS

165 patients with recurrent acute anterior uveitis were divided into two groups: HLA B27-positive (group 1, 60 patients) and HLA B27-negative (group 2, 105 patients). A comparison between the two groups was performed.

RESULTS

Unilateral involvement was higher in group 1 (p = .046), and more simultaneous bilateral cases occurred in group 2 (p = .004). Group 1 was more correlated to systemic diseases than group 2 (50 versus 17.1%, p < .001), particularly to ankylosing spondylitis (35 versus 3.8%, p < .001). Uveitis was diagnosed before spondylitis in 57% of patients. In groups 1 and 2 an immunosuppressive therapy was administered to 20 and 9.5% of patients but was exclusively given to control uveitis in 1.6 and in 2.8% of cases, respectively.

CONCLUSIONS

A strong association between HLA B27 uveitis and ankylosing spondylitis was confirmed and usually uveitis preceded rheumatological involvement.

摘要

目的

报告 HLA B27 急性前葡萄膜炎的临床特征和预后。

方法

将 165 例复发性急性前葡萄膜炎患者分为两组：HLA B27 阳性（组 1，60 例）和 HLA B27 阴性（组 2，105 例）。对两组进行比较。

结果

组 1 单侧受累比例较高（p =.046），组 2 同时双侧受累比例较高（p =.004）。组 1 与全身疾病的相关性高于组 2（50 比 17.1%，p <.001），特别是强直性脊柱炎（35 比 3.8%，p <.001）。57%的患者在出现脊柱炎前被诊断为葡萄膜炎。在组 1 和组 2 中，分别有 20%和 9.5%的患者接受了免疫抑制治疗，但分别仅有 1.6%和 2.8%的患者接受了免疫抑制治疗以控制葡萄膜炎。