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[强直性脊柱炎和反应性关节炎中的 HLA B 27 葡萄膜炎]

[HLA B 27 uveitis in ankylosing spondylitis and reactive arthritis].

作者信息

Dumbrăveanu Lilia, Cuşnir V, Groppa Liliana, Calinina Liana

机构信息

Catedra Oftalmologie, USMF "N.Testemiţanu", Chişinaău, Republica Moldova.

出版信息

Oftalmologia. 2010;54(1):29-35.

Abstract

Clinical features of uveitis HLA B27 in patients with uveitis associated with ankylosing spondylitis and reactive arthritis. The study was made on 64 patients with uveitis treated in the municipal hospital between 2005-2008. The diagnosis was established after a complex ophthalmologic investigation. Histocompatibility HLA-B27 was determined in all groups of patients. Each patient was consulted by the rheumatologist. In the study were included 50 (78%) men and 14 (22%) women. The frequency of HLA B27+ was 72%. At HLA B27+ associated with ankylosing spondylitis and reactive arthritis is present in the anterior form in 85%, unilateral affection in 92%. Their evolution is chronic in 17% and has a tendency for recidivism in 11% of patients. HLA B27 is a genetic factor of uveitis associated with spondylarthropathies in 72%. The study determined the disease in 78% of men, 72% were acute, 85% were anterior and 92% were unilateral. The study of HLA B27 in patients with uveitis is one of the shortest ways for the earlier diagnosis of ankylosing spondylitis.

摘要

与强直性脊柱炎和反应性关节炎相关的葡萄膜炎患者中葡萄膜炎HLA B27的临床特征。该研究对2005年至2008年间在市医院接受治疗的64例葡萄膜炎患者进行。在进行全面的眼科检查后确立诊断。对所有患者组进行组织相容性HLA - B27检测。每位患者都由风湿病学家会诊。研究纳入了50名(78%)男性和14名(22%)女性。HLA B27阳性率为72%。与强直性脊柱炎和反应性关节炎相关的HLA B27阳性患者中,85%为前部葡萄膜炎形式,92%为单眼受累。其病程17%为慢性,11%的患者有复发倾向。72%的与脊柱关节病相关的葡萄膜炎患者中,HLA B27是一个遗传因素。该研究确定78%的男性患有该疾病,72%为急性,85%为前部葡萄膜炎,92%为单眼受累。对葡萄膜炎患者进行HLA B27检测是早期诊断强直性脊柱炎的最短途径之一。

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