Department of Internal Medicine, Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Republic of Korea.
J Gastroenterol Hepatol. 2010 Mar;25(3):519-25. doi: 10.1111/j.1440-1746.2009.06147.x.
Colorectal cancer screening is recommended for average-risk persons beginning at age 50. However, information about the incidence and risk factors of precursor adenoma in preceding decades is limited. The aim of this study was to determine the prevalence and risk factors of colorectal adenoma in persons aged 40-49 years and to compare the data with those aged 30-39 years and 50-59 years.
A cross-sectional study of 5254 asymptomatic subjects who underwent screening colonoscopy was conducted. Data were stratified by age into three groups: 608 aged 30-39 years, 1930 aged 40-49 years, and 2716 aged 50-59 years.
Prevalence of overall adenomas was 10.4% in the 30-39 years age group, 22.2% in the 40-49 years age group, and 32.8% in the 50-59 years age group. Advanced adenoma was found in 0.7% of the 30-39 years age group, 2.7% of the 40-49 years age group, and 4.1% of the 50-59 years age group. In the 40-49 years age group, male sex and current smoking habits showed associations with low-risk adenoma after multiple adjustments. Moreover, male sex (odds ratio [OR] = 1.55, 95% confidence interval [CI]: 1.02-3.23), current smoking (OR = 1.58, 95%CI: 1.06-3.50), and family history of colorectal cancer (OR = 2.54, 95%CI: 1.16-5.56) were independent predictors of advanced adenoma in this age group.
Prevalence of adenoma in subjects aged 40-49 years was higher than in previous studies. Male sex and current smoking habits along with a family history of colorectal cancer were associated with advanced adenoma in this age group.
建议 50 岁开始对一般风险人群进行结直肠癌筛查。然而，关于前几十年前体腺瘤的发病率和危险因素的信息有限。本研究旨在确定 40-49 岁人群中结直肠腺瘤的患病率和危险因素，并将这些数据与 30-39 岁和 50-59 岁人群的数据进行比较。
对 5254 名无症状接受筛查性结肠镜检查的受试者进行了一项横断面研究。数据按年龄分为三组：30-39 岁组 608 人，40-49 岁组 1930 人，50-59 岁组 2716 人。
30-39 岁年龄组总体腺瘤患病率为 10.4%，40-49 岁年龄组为 22.2%，50-59 岁年龄组为 32.8%。在 30-39 岁年龄组中发现 0.7%有高级别腺瘤，在 40-49 岁年龄组中为 2.7%，在 50-59 岁年龄组中为 4.1%。在 40-49 岁年龄组中，经过多次调整后，男性和当前吸烟习惯与低风险腺瘤有关。此外，男性（比值比[OR] = 1.55，95%置信区间[CI]：1.02-3.23）、当前吸烟（OR = 1.58，95%CI：1.06-3.50）和结直肠癌家族史（OR = 2.54，95%CI：1.16-5.56）是该年龄组中高级别腺瘤的独立预测因素。
40-49 岁人群中腺瘤的患病率高于以往研究。男性和当前吸烟习惯以及结直肠癌家族史与该年龄组的高级别腺瘤有关。
