Department of Internal Medicine, Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center, 39th Floor, Gangnam Finance Center, 737 Yeoksam-dong, Gangnam-gu, Seoul, 135-984, Korea.
Cancer Causes Control. 2013 Sep;24(9):1717-26. doi: 10.1007/s10552-013-0247-4. Epub 2013 Jun 11.
To evaluate physical activity and other lifestyle risk factors in relation to the prevalence of colorectal adenomas in asymptomatic Koreans.
A total of 1,526 asymptomatic subjects who underwent a colonoscopy were enrolled. Lifestyle factors such as physical activity and smoking data were obtained using a questionnaire. The subjects were grouped into three exposure levels by tertiles of metabolic equivalent hours per week. We evaluated the risk factors in subjects with adenomas by risk stratification (low-risk adenoma group vs. high-risk adenoma group) and by anatomic location (proximal colon, distal colon, rectum, and multiple locations). The high-risk adenoma group was defined as subjects with advanced adenomas or multiple (≥ 3) adenomas.
A total of 456 participants had colorectal adenomas, and 861 had no polyps. In multivariate analyses, higher levels of physical activity were associated with a significantly decreased risk of colorectal adenomas (OR = 0.56, 95% CI 0.40-0.79). This inverse association was stronger for the risk of high-risk adenomas (OR = 0.39, 95% CI 0.21-0.73) than for low-risk adenomas (OR = 0.62, 95% CI 0.43-0.89). The negative relation of physical activity was significant for distal colon adenomas (OR = 0.54, 95% CI 0.30-0.95) and the adenomas with multiple locations (OR = 0.39, 95% CI 0.21-0.72).
Increased physical activity is associated with a reduced prevalence of colorectal adenomas. The inverse association between physical activity and adenoma was stronger for the risk of advanced or multiple adenomas.
评估与无症状韩国人群结直肠腺瘤患病率相关的体力活动和其他生活方式风险因素。
共纳入 1526 名接受结肠镜检查的无症状受试者。使用问卷获得生活方式因素，如体力活动和吸烟数据。受试者按每周代谢当量小时的三分位将暴露水平分为三组。我们通过风险分层（低危腺瘤组与高危腺瘤组）和解剖部位（近端结肠、远端结肠、直肠和多个部位）评估腺瘤患者的危险因素。高危腺瘤组定义为有进展性腺瘤或多个（≥3 个）腺瘤的患者。
共有 456 名参与者患有结直肠腺瘤，861 名参与者无息肉。多变量分析显示，体力活动水平较高与结直肠腺瘤的风险显著降低相关（OR=0.56，95%CI 0.40-0.79）。这种反比关系对于高危腺瘤的风险（OR=0.39，95%CI 0.21-0.73）比低危腺瘤的风险（OR=0.62，95%CI 0.43-0.89）更强。体力活动与远端结肠腺瘤（OR=0.54，95%CI 0.30-0.95）和多个部位的腺瘤（OR=0.39，95%CI 0.21-0.72）的相关性具有统计学意义。
增加体力活动与结直肠腺瘤的患病率降低相关。体力活动与腺瘤之间的反比关系在高危或多发性腺瘤的风险中更强。
