ATP/ADP转位酶抑制剂膨压素对小鼠胰腺β细胞电活动的抑制作用。
Inhibition of electrical activity in mouse pancreatic beta-cells by the ATP/ADP translocase inhibitor, bongkrekic acid.
作者信息
Kiranadi B, Bangham J A, Smith P A
机构信息
University Laboratory of Physiology, Oxford, UK.
出版信息
FEBS Lett. 1991 May 20;283(1):93-6. doi: 10.1016/0014-5793(91)80561-g.
Bongkrekic acid causes fatal food poisoning which is associated with hyperglycaemia. Here we demonstrate that bongkrekic acid, a potent inhibitor of the mitochondrial ATP/ADP translocase, inhibits glucose-induced electrical activity in the pancreatic beta-cell through the stimulation of ATP-sensitive potassium channel (K-ATP-channel) activity. By comparison of its effects with those of oligomycin, we suggest that bongkrekic acid acts by the inhibition of glucose metabolism and may induce hyperglycaemia by impairing beta-cell function.
邦克酸会导致与高血糖相关的致命食物中毒。在此我们证明，作为线粒体ATP/ADP转位酶的强效抑制剂，邦克酸通过刺激ATP敏感性钾通道（K-ATP通道）活性来抑制胰腺β细胞中葡萄糖诱导的电活动。通过将其作用与寡霉素的作用进行比较，我们认为邦克酸通过抑制葡萄糖代谢起作用，并且可能通过损害β细胞功能诱导高血糖。
Zotero 插件