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新鲜骨软骨同种异体移植治疗距骨骨软骨病变。

Fresh osteochondral allografting for osteochondral lesions of the talus.

机构信息

Department of Orthopaedic Surgery, University of California-San Diego, La Jolla, CA 92037, USA.

出版信息

Foot Ankle Int. 2010 Apr;31(4):283-90. doi: 10.3113/FAI.2010.0283.

DOI:10.3113/FAI.2010.0283
PMID:20371013
Abstract

BACKGROUND

Osteochondral lesions of the talus (OLT) are relatively common sequelae of traumatic injuries involving the talus. We report on clinical outcomes of osteochondral allografting (OCA) of the talus for refractory, symptomatic OLT.

MATERIALS AND METHODS

OCA was performed in 12 ankles in 11 patients with OLT. All involved partial, unipolar grafts of the talar dome, implanted through an anterior approach without osteotomy, under temporary distraction. Clinical evaluation was performed utilizing the Olerud-Molander Ankle Score (OMAS). Subjective outcome measures included patient questionnaires evaluating pain, function, and satisfaction. Eleven patients (seven males, four females) had a mean age of 35.5 (range, 26 to 57) years. One patient had bilateral involvement. Six OLT affected the medial, six the lateral talar dome. Patients had an average of 1.8 previous surgeries (range, 1 to 5). Mean followup was 38 (range, 24 to 107) months.

RESULTS

Mean OMAS improved from 28 to 71 points (p < 0.05). Three had further surgery; overall graft survival rate was 10/12. Of surviving grafts, 30% recorded excellent (OMAS: 100 to 91 points), 20% good (OMAS: 90 to 61 points), 30% fair (OMAS: 60 to 31 points), and 20% poor (OMAS: 30 to 0 points) outcomes. All non-failing patients completed questionnaires; 90% were satisfied, 80% reported reduced pain, and 60% improved function.

CONCLUSION

OCA achieved good to excellent results in five of 12 patients, resulting in significant improvement in function and pain with good patient satisfaction. All but one patient avoided arthrodesis. Partial talus OCA is a reasonable treatment option for appropriately selected patients with unipolar OLT.

摘要

背景

距骨骨软骨损伤(OLT)是涉及距骨的创伤性损伤的常见后遗症。我们报告了使用同种异体骨软骨移植(OCA)治疗难治性、有症状的 OLT 的临床结果。

材料和方法

11 名患者的 12 个踝关节接受了 OCA。所有病例均为距骨穹窿的部分、单极移植物,通过不截骨的前入路,在临时牵开器下植入。临床评估采用 Olerud-Molander 踝关节评分(OMAS)。主观结果测量包括评估疼痛、功能和满意度的患者问卷。11 名患者(7 名男性,4 名女性)的平均年龄为 35.5 岁(范围,26 至 57 岁)。1 名患者为双侧受累。6 例 OLT 累及内侧距骨穹窿,6 例累及外侧距骨穹窿。患者平均有 1.8 次既往手术(范围,1 至 5 次)。平均随访时间为 38 个月(范围,24 至 107 个月)。

结果

OMAS 平均从 28 分提高到 71 分(p < 0.05)。3 例患者进行了进一步手术;总的移植物存活率为 10/12。在存活的移植物中,30%的患者记录为优(OMAS:100 至 91 分),20%为良(OMAS:90 至 61 分),30%为可(OMAS:60 至 31 分),20%为差(OMAS:30 至 0 分)。所有非失败患者均完成了问卷调查;90%的患者满意,80%的患者报告疼痛减轻,60%的患者功能改善。

结论

在 12 例患者中,有 5 例患者的 OCA 取得了良好至优秀的结果,导致功能和疼痛显著改善,患者满意度高。除 1 例患者外,其余患者均避免了融合。对于适当选择的单极 OLT 患者,部分距骨 OCA 是一种合理的治疗选择。

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