Haran-Ghera N
J Natl Cancer Inst. 1978 Mar;60(3):707-10. doi: 10.1093/jnci/60.3.707.
A transplantation bioassay method was used to verify the presence of preleukemia cells in C57BL/6 mice shortly after leukemogenic treatment or in relation to age increase. Preleukemia cells were identified mainly among bone marrow cells of old C57BL/6 mice or within 10 to 30 days after leukemogenic treatment of young mice with radiation-induced leukemia virus variants, fractionated doses of irradiation, or 7,12-dimethylbenz[a]anthracene (DMBA), although the overt disease did not occur until many months later. Mice could carry preleukemia cells without necessarily developing overt leukemia. Since the leukemogenic agents used in the present studies induced T-leukemias, the role of the thymus in the induction of preleukemia cells was tested. Thymectomy affected viral transformation but did not diminish the number of preleukemia cells induced by DMBA or X-ray.
采用移植生物测定法来验证C57BL/6小鼠在致白血病治疗后不久或随着年龄增长是否存在白血病前期细胞。白血病前期细胞主要在老年C57BL/6小鼠的骨髓细胞中被鉴定出来，或者在幼鼠接受辐射诱导的白血病病毒变体、分次照射剂量或7,12-二甲基苯并[a]蒽（DMBA）致白血病治疗后的10至30天内被鉴定出来，尽管明显的疾病直到数月后才出现。小鼠可以携带白血病前期细胞而不一定发展为明显的白血病。由于本研究中使用的致白血病剂诱导T细胞白血病，因此测试了胸腺在白血病前期细胞诱导中的作用。胸腺切除术影响病毒转化，但并未减少DMBA或X射线诱导的白血病前期细胞数量。
