Haran-Ghera N
Proc Natl Acad Sci U S A. 1980 May;77(5):2923-6. doi: 10.1073/pnas.77.5.2923.
Potentially leukemic cells have been identified among bone marrow cells of AKR/J mice from the age of 14 days onward. Transfer of AKR/J bone marrow into irradiated hybrid mice (AKR/J X DBA/2)F1 caused a high leukemia incidence (50-100%) of AKR origin, very often within a short latent period. Similar transfer of AKR/J marrow into irradiated AKR/J recipients did not enhance spontaneous tumor development. In contrast to the leukemic AKR cells that express the T-cell surface component Thy-1.1, the potential leukemic cells among bone marrow cells of young AKR mice were shown to lack the expression of this antigen. The development of preleukemic AKR marrow into overt leukemia in hybrid mice was dependent on the presence of an intact thymus and exposure of the recipients to x-rays shortly before marrow transfer. Evidently, preleukemic AKR bone marrow undergoes sequential changes, affected by host factors, leading ultimately to development of overt leukemia.
从14日龄起，就在AKR/J小鼠的骨髓细胞中发现了潜在的白血病细胞。将AKR/J骨髓移植到经辐射的杂交小鼠（AKR/J×DBA/2）F1中，会导致很高的源自AKR的白血病发病率（50%-100%），而且通常在很短的潜伏期内就会发病。将AKR/J骨髓类似地移植到经辐射的AKR/J受体中，并不会促进自发肿瘤的发展。与表达T细胞表面成分Thy-1.1的白血病AKR细胞不同，年轻AKR小鼠骨髓细胞中的潜在白血病细胞被证明缺乏该抗原的表达。杂交小鼠中白血病前期的AKR骨髓发展为明显的白血病，依赖于完整胸腺的存在以及受体在骨髓移植前不久接受X射线照射。显然，白血病前期的AKR骨髓会发生一系列受宿主因素影响的变化，最终导致明显白血病的发展。
