Yamamoto Tatsuya, Uchiyama Tomoyuki, Takahashi Hirokatsu, Himuro Keiichi, Kanai Kazuaki, Kuwabara Satoshi
Department of Neurology, Graduate School of Medicine, Chiba University, Chiba.
Intern Med. 2010;49(7):707-8. doi: 10.2169/internalmedicine.49.3087. Epub 2010 Apr 1.
Although immunosuppressive effects of antiepileptic drug are well known, serious complications of antiepileptic drug are rare. We report a case of hypogammaglobulinemia associated with aplasia of B lymphocytes after carbamazepine treatment. Despite repeated intravenous immunoglobulin replacement therapy, this condition persisted for more than three months. The present case suggested that routine monitoring of the blood cell count and serum levels of immunoglobulin are important in patients treated with carbamazepine, and a lymphocyte subpopulation study is valuable in cases of hypogammaglobulinemia.
尽管抗癫痫药物的免疫抑制作用众所周知，但其严重并发症却很罕见。我们报告一例卡马西平治疗后出现与B淋巴细胞发育不全相关的低丙种球蛋白血症病例。尽管反复进行静脉注射免疫球蛋白替代治疗，这种情况仍持续了三个多月。本病例提示，对于接受卡马西平治疗的患者，常规监测血细胞计数和免疫球蛋白血清水平很重要，而淋巴细胞亚群研究对于低丙种球蛋白血症病例很有价值。
