Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL, USA.
EMBO J. 2010 Apr 7;29(7):1163-4. doi: 10.1038/emboj.2010.40.
By reconstituting the recently discovered prokaryotic ubiquitin-like protein (Pup)--proteasome degradation system in vitro, Weber-Ban and colleagues (Striebel et al, 2010) elucidate its mechanism and describe a surprising variation on the established principles of protease targeting. Nevertheless, their findings suggest that the bacterial and eukaryotic systems follow the same overall principles even if the details differ.
通过在体外重建最近发现的原核泛素样蛋白 (Pup) - 蛋白酶体降解系统，Weber-Ban 和同事（Striebel 等人，2010）阐明了其机制，并描述了在已建立的蛋白酶靶向原则上的一个惊人变化。然而，他们的发现表明，即使细节不同，细菌和真核系统也遵循相同的总体原则。
