Department of Cell Biology, University of Alberta, Edmonton, AB, T6G 2H7, Canada.
Cell Mol Life Sci. 2010 Jul;67(13):2215-30. doi: 10.1007/s00018-010-0325-7. Epub 2010 Apr 8.
The trafficking of macromolecules between the cytoplasm and the nucleus is controlled by the nuclear pore complexes (NPCs) and various transport factors that facilitate the movement of cargos through the NPCs and their accumulation in the target compartment. While their functions in transport are well established, an ever-growing number of observations have also linked components of the nuclear transport machinery to processes that control chromosome segregation during mitosis, including spindle assembly, kinetochore function, and the spindle assembly checkpoint. In this review, we will discuss this evolving area of study and emerging hypotheses that propose key roles for components of the nuclear transport apparatus in mitotic progression.
细胞质和细胞核之间的大分子运输是由核孔复合体(NPCs)和各种运输因子控制的,这些运输因子促进了货物通过 NPCs 的运动及其在靶区的积累。虽然它们在运输中的功能已经得到很好的证实,但越来越多的观察结果也将核运输机制的成分与控制有丝分裂过程中染色体分离的过程联系起来,包括纺锤体组装、动粒功能和纺锤体组装检查点。在这篇综述中,我们将讨论这个不断发展的研究领域和新兴假说,这些假说提出了核运输设备的成分在有丝分裂进程中的关键作用。