Research and Clinical Center for Infertility, Department of Obstetrics and Gynecology, Shahid Sadoughi University of Medical Science, Safaieh, Yazd, Iran.
J Assist Reprod Genet. 2010 Jul;27(7):357-63. doi: 10.1007/s10815-010-9412-9. Epub 2010 Apr 6.
Controlled ovarian hyperstimulation has been shown to advance endometrial maturation and adversely affects implantation in ART. It has been reported that there is a better embryo-endometrium synchrony in frozen-thawed embryo transfer cycles than fresh embryo transfer cycles. The objective of this study was to compare ongoing pregnancy rates between fresh ET and FET cycles.
In an open prospective, controlled study, the patients who were classified as high responders, were randomized to either fresh ET or FET. The embryos in FET group were cryopreserved with vitrification by Cryotop method.
A total of 374 patients were included, 187 of which were randomized to FET and 187 to fresh ET. There were 39% (n = 73) ongoing pregnancy in FET group compared with 27.8% (n = 52) in fresh ET group[odds ratio = 1.66;95% confidence interval = 1.07-2.56; p = 0.02].
FETs can be performed instead of fresh ETs to improve the outcome of ART in highly selected patients.
控制性卵巢刺激已被证明可促进子宫内膜成熟,并对 ART 中的着床产生不利影响。据报道,冷冻胚胎移植周期中胚胎-子宫内膜同步性优于新鲜胚胎移植周期。本研究旨在比较新鲜胚胎移植(ET)和冷冻胚胎移植(FET)周期的持续妊娠率。
在一项开放前瞻性对照研究中,将高反应患者随机分为新鲜 ET 或 FET 组。FET 组的胚胎采用 Cryotop 法玻璃化冷冻保存。
共纳入 374 例患者,其中 187 例随机分为 FET 组,187 例随机分为新鲜 ET 组。FET 组的持续妊娠率为 39%(n=73),新鲜 ET 组为 27.8%(n=52)[比值比=1.66;95%置信区间=1.07-2.56;p=0.02]。
对于高度选择的患者,可进行 FET 以代替新鲜 ET,从而提高 ART 的结局。