Pavlishchuk S A
Kardiologiia. 1978 Jan;18(1):96-102.
The indices of microcirculatory hemostasis were studied in 955 persons, 200 of whom were healthy while 755 had diseases of the heart and vessels. The results were compared with blood fibrinolytic and coagulation activity and with the functional condition of the basophil-mast cell apparatus. A reverse trend in the functional shifts of microcirculatory and plasmo-coagulative hemostasis in the reaction of emergency adaptation was established. Delayed formation and increased resistance of platelet aggregates with simultaneous decrease in the number of platelets in circulation were revealed in cardiovascular diseases during a remission, which reflects intensified expenditure of the platelets or their aggregation energy in the microcirculatory channel. The administration of exogenous heparin, just like the period of basophil degranulation in stresses of various origin, is attended with distinct platelet hyperfunction which allows small doses of heparin to be used for the prevention of diapedetic hemorrhages in hypertensive disease.
对955人进行了微循环止血指标的研究，其中200人健康，755人患有心脏和血管疾病。将结果与血液纤溶和凝血活性以及嗜碱性粒细胞 - 肥大细胞装置的功能状态进行了比较。确定了在应急适应反应中微循环和血浆 - 凝血止血功能变化的相反趋势。在缓解期的心血管疾病中，发现血小板聚集体形成延迟且抵抗力增加，同时循环中的血小板数量减少，这反映了微循环通道中血小板或其聚集能量的消耗增加。外源性肝素的给药，就像各种来源应激中嗜碱性粒细胞脱颗粒期一样，伴随着明显的血小板功能亢进，这使得小剂量肝素可用于预防高血压病中的漏出性出血。
