Kirichenko L L, Porunova A K, Smirnov V V, Radzevich A E, Besprozvannyĭ A B
Kardiologiia. 1989 Dec;29(12):85-90.
The paper provides the results of studies into plasmapheresis-induced changes in the thrombocytic link of hemostasis and microcirculation in 40 patients with coronary heart disease (CHD). Repeated sessions of plasmapheresis (P) were found to produce an inhibitory effect on platelet aggregation and to improve microcirculation in CHD patients with signs of increased platelet functional activity. In CHD patients with low platelet functional activity, the first P session was demonstrated to cause an increase in platelet functional activity whereas the subsequent sessions inhibited platelet aggregation. No significant microcirculatory improvement was seen in this group of patients. Heparin and rheopolyglucin given to control patients exerted no substantial effect on the thrombocytic link of hemostasis and microcirculation.
本文给出了对40例冠心病（CHD）患者进行血浆置换引起的止血和微循环中血小板环节变化的研究结果。发现重复进行血浆置换（P）对血小板聚集有抑制作用，并改善了有血小板功能活性增加迹象的冠心病患者的微循环。在血小板功能活性较低的冠心病患者中，首次血浆置换可使血小板功能活性增加，而随后的置换则抑制血小板聚集。该组患者未见明显的微循环改善。给予对照患者肝素和右旋糖酐对止血和微循环的血小板环节无实质性影响。
