自愿运动可增加脊髓中的少突胶质细胞生成。
Voluntary exercise increases oligodendrogenesis in spinal cord.
机构信息
Intellectual and Developmental Disability Research Center, Semel Institute for Neuroscience and Human Behavior Department of Neurobiology, David Geffen, School of Medicine at UCLA, Los Angeles, California 90095, USA.
出版信息
Int J Neurosci. 2010 Apr;120(4):280-90. doi: 10.3109/00207450903222741.
Exercise has been shown to increase hippocampal neurogenesis, but the effects of exercise on oligodendrocyte generation have not yet been reported. In this study, we evaluated the hypothesis that voluntary exercise may affect neurogenesis, and more in particular, oligodendrogenesis in the thoracic segment of the intact spinal cord of adult nestin-GFP transgenic mice. Voluntary exercise for 7 and 14 days increased nestin-GFP expression around the ependymal area. In addition, voluntary exercise for 7 days significantly increased nestin-GFP expression in both the white and gray matter of the thoracic segment of the intact spinal cord, whereas, 14-day exercise decreased nestin-GFP expression. Markers for immature oligodendrocytes (transferrin and CNPase) were significantly increased after 7 days of voluntary exercise. These results suggest that voluntary exercise positively influences oligodendrogenesis in the intact spinal cord, emphasizing the beneficial effects of voluntary exercise as a possible co-treatment for spinal cord injury.
运动已被证明可以增加海马体神经发生，但运动对少突胶质细胞生成的影响尚未见报道。在这项研究中，我们评估了这样一个假设，即自愿运动可能会影响神经发生，更具体地说，可能会影响成年巢蛋白 GFP 转基因小鼠完整脊髓胸段的少突胶质细胞发生。7 天和 14 天的自愿运动增加了室管膜区周围的巢蛋白 GFP 表达。此外，7 天的自愿运动显著增加了完整脊髓胸段白质和灰质中的巢蛋白 GFP 表达，而 14 天的运动则降低了巢蛋白 GFP 的表达。7 天的自愿运动后，不成熟少突胶质细胞的标志物（转铁蛋白和 CNPase）显著增加。这些结果表明，自愿运动对完整脊髓中的少突胶质细胞发生有积极影响，强调了自愿运动作为脊髓损伤可能的联合治疗的有益作用。
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