Iranian Center of Neurological Research, Tehran University of Medical Sciences, Tehran, Iran.
Int J Neurosci. 2010 Apr;120(4):301-4. doi: 10.3109/00207451003695690.
Oxidative stress through the changes in the levels of reactive oxygen species and antioxidative parameters can cause various neurological disorders. The aim of the present study was to show antioxidant activity (AOA) and malondialdehyde (MDA) levels in affected people with Guillain-Barre syndrome (GBS) and multiple sclerosis (MS). A total of 15 GBS patients, 13 MS patients, and 15 age and sex matched controls were included in this study. MDA and AOA values were determined in both cerebrospinal fluid (CSF) and serum, spectrophotometrically. We have shown an increase in the values of MDA in the CSF of both GBS and MS patients (0.32 +/- 0.073 and 0.22 +/- 0.06 micromol/L) compared to the control (undetectable levels). Furthermore, a significant decrease in the serum MDA levels was shown in both GBS and MS patients (0.81 +/- 0.18 and 0.73 +/- 0.18 micromol/L) when compared to the control (1.7 +/- 0.46 micromol/L). A decrease was shown for serum AOA in both GBS (1.7 +/- 0.21 mmol/L) and MS patients (2.6 +/- 0.62 mmol/L) when compared to the control (3.2 +/- 0.17 mmol/L). However, a significant increase in the values of CSF AOA was shown in both MS and GBS patients (1.47 +/- 0.19 and 1.42 +/- 0.26 mmol/L) compared to the control (0.71 +/- 0.19 mmol/L). An imbalance between the levels of AOA and MDA in both CSF and serum can be followed in both MS and GBS patients.
氧化应激通过活性氧和抗氧化参数水平的变化可引起各种神经紊乱。本研究旨在展示影响格林-巴利综合征（GBS）和多发性硬化症（MS）患者的抗氧化活性（AOA）和丙二醛（MDA）水平。本研究共纳入 15 例 GBS 患者、13 例 MS 患者和 15 名年龄和性别匹配的对照者。采用分光光度法测定脑脊液（CSF）和血清中的 MDA 和 AOA 值。我们发现，与对照组（未检出水平）相比，GBS 和 MS 患者 CSF 中的 MDA 值均升高（0.32 +/- 0.073 和 0.22 +/- 0.06 微摩尔/升）。此外，与对照组（1.7 +/- 0.46 微摩尔/升）相比，GBS 和 MS 患者的血清 MDA 水平均显著降低（0.81 +/- 0.18 和 0.73 +/- 0.18 微摩尔/升）。与对照组（3.2 +/- 0.17 微摩尔/升）相比，GBS（1.7 +/- 0.21 毫摩尔/升）和 MS 患者（2.6 +/- 0.62 毫摩尔/升）的血清 AOA 均降低。然而，与对照组（0.71 +/- 0.19 毫摩尔/升）相比，MS 和 GBS 患者的 CSF AOA 值均显著升高（1.47 +/- 0.19 和 1.42 +/- 0.26 毫摩尔/升）。在 MS 和 GBS 患者中，CSF 和血清中的 AOA 和 MDA 水平之间的失衡都可以观察到。
