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神经生长抑制因子-A 表达在神经干细胞表面。

Nogo-A expresses on neural stem cell surface.

机构信息

Institute of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

出版信息

Int J Neurosci. 2010 Mar;120(3):201-5. doi: 10.3109/00207450903506502.

DOI:10.3109/00207450903506502
PMID:20374087
Abstract

Nogo-A, as a myelin-associated molecule to inhibit axon regeneration in the injured adult central nervous system (CNS), has been detected to be enriched in numerous populations of cells in CNS. In this study, we found that Nogo-A was also expressed on the surface of neural stem cells (NSCs). The possible effects of NSCs-expressed Nogo-A on the NSC transplantation for CNS repair were discussed.

摘要

Nogo-A 是一种与髓鞘相关的分子，可抑制成年中枢神经系统 (CNS) 中的轴突再生，现已发现在 CNS 中的许多细胞群体中富含 Nogo-A。在这项研究中，我们发现 Nogo-A 也在神经干细胞 (NSC) 的表面表达。探讨了 NSC 表达的 Nogo-A 对 CNS 修复中 NSC 移植的可能影响。

相似文献

1
Nogo-A expresses on neural stem cell surface.神经生长抑制因子-A 表达在神经干细胞表面。
Int J Neurosci. 2010 Mar;120(3):201-5. doi: 10.3109/00207450903506502.
2
[Influence of Nogo extracellular peptide residues 1-40 gene modification on survival and differentiation of neural stem cells after transplantation].[Nogo细胞外肽段1-40基因修饰对移植后神经干细胞存活及分化的影响]
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NOGO mRNA expression in adult and fetal human and rat nervous tissue and in weight drop injury.NOGO信使核糖核酸在成年和胎儿的人类及大鼠神经组织中的表达以及在重物坠落损伤中的表达。
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Patterns of Nogo mRNA and protein expression in the developing and adult rat and after CNS lesions.发育中和成年大鼠以及中枢神经系统损伤后Nogo信使核糖核酸和蛋白质表达模式。
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Human neural stem cells promote corticospinal axons regeneration and synapse reformation in injured spinal cord of rats.人神经干细胞促进大鼠脊髓损伤后皮质脊髓轴突再生和突触重塑。
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Activity-induced and developmental downregulation of the Nogo receptor.由活动诱导及发育引起的Nogo受体下调。
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Nogo-receptor gene activity: cellular localization and developmental regulation of mRNA in mice and humans.Nogo受体基因活性：小鼠和人类中mRNA的细胞定位与发育调控
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The interaction of Nogo-66 receptor with Nogo-p4 inhibits the neuronal differentiation of neural stem cells.Nogo-66受体与Nogo-p4的相互作用抑制神经干细胞的神经元分化。
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miR-182-5p Regulates Nogo-A Expression and Promotes Neurite Outgrowth of Hippocampal Neurons In Vitro.miR-182-5p调控Nogo-A表达并促进体外海马神经元的轴突生长。
Pharmaceuticals (Basel). 2022 Apr 25;15(5):529. doi: 10.3390/ph15050529.
2
[Experimental study of lentivirus-mediated Nogo extracellular peptide residues 1-40 gene and neurotrophin 3 gene co-transduction in neural stem cells].慢病毒介导的Nogo细胞外肽残基1-40基因与神经营养因子3基因共转导神经干细胞的实验研究
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2018 Apr 15;32(4):420-427. doi: 10.7507/1002-1892.201710079.
3
Building a central nervous system: The neural stem cell lineage revealed.
构建中枢神经系统：神经干细胞谱系揭秘。
Neurogenesis (Austin). 2017 Apr 28;4(1):e1300037. doi: 10.1080/23262133.2017.1300037. eCollection 2017.
4
Nogo-A expression dynamically varies after spinal cord injury.脊髓损伤后，Nogo-A的表达会动态变化。
Neural Regen Res. 2015 Feb;10(2):225-9. doi: 10.4103/1673-5374.152375.
5
The Neural Stem Cell Microenvironment: Focusing on Axon Guidance Molecules and Myelin-Associated Factors.神经干细胞微环境：聚焦于轴突导向分子和髓鞘相关因子
J Mol Neurosci. 2015 Aug;56(4):887-897. doi: 10.1007/s12031-015-0538-1. Epub 2015 Mar 11.
6
Nogo-A is a negative regulator of CNS angiogenesis.Nogo-A 是中枢神经系统血管生成的负调节剂。
Proc Natl Acad Sci U S A. 2013 May 21;110(21):E1943-52. doi: 10.1073/pnas.1216203110. Epub 2013 Apr 26.
7
Neutralization of LINGO-1 during in vitro differentiation of neural stem cells results in proliferation of immature neurons.在神经干细胞体外分化过程中中和 LINGO-1 会导致未成熟神经元增殖。
PLoS One. 2012;7(1):e29771. doi: 10.1371/journal.pone.0029771. Epub 2012 Jan 3.