Department of Internal Medicine, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia.
Int J Rheum Dis. 2009 Sep;12(3):211-5. doi: 10.1111/j.1756-185X.2009.01412.x.
The objectives of this study are to provide data regarding the prevalence of anti-cyclic citrullinated peptide (CCP) antibodies in Malaysian rheumatoid arthritis (RA) patients and to correlate the levels of anti-CCP antibody with the Disease Activity Score (DAS).
We studied the prevalence of anti-CCP antibodies in 51 RA patients attending our clinic and 29 controls. We also looked for correlation between anti-CCP antibody levels with the DAS and parameters such as duration of disease, rheumatoid factor (RF) and disease-modifying anti rheumatic drug (DMARD) usage.
None of the controls demonstrated anti-CCP antibodies. Forty-one out of 51 patients (80.4%) were positive for anti-CCP antibodies. Sensitivity and specificity were 80.4% and 100% respectively in this study. Anti-CCP levels correlated significantly with rheumatoid factor, but no correlation was observed with the other parameters.
Anti-CCP antibody is prevalent in Malaysian RA patients at 80.4% and more sensitive than RF in our cohort of established RA patients. Even though the anti-CCP levels correlated with RF, it did not show correlation with DAS.
本研究旨在提供马来西亚类风湿关节炎（RA）患者抗环瓜氨酸肽（CCP）抗体流行率的数据，并将抗 CCP 抗体水平与疾病活动评分（DAS）相关联。
我们研究了 51 例在我院就诊的 RA 患者和 29 例对照者的抗 CCP 抗体流行率。我们还观察了抗 CCP 抗体水平与 DAS 以及疾病持续时间、类风湿因子（RF）和疾病修饰抗风湿药物（DMARD）使用等参数之间的相关性。
对照组均未检测到抗 CCP 抗体。51 例患者中有 41 例（80.4%）抗 CCP 抗体阳性。本研究中，敏感性和特异性分别为 80.4%和 100%。抗 CCP 水平与 RF 显著相关，但与其他参数无相关性。
抗 CCP 抗体在马来西亚 RA 患者中流行率为 80.4%，在我们的确诊 RA 患者队列中比 RF 更敏感。尽管抗 CCP 水平与 RF 相关，但与 DAS 无相关性。
