Gerald J. and Dorothy R. Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, USA.
J Nutr. 2010 Jun;140(6):1099-104. doi: 10.3945/jn.109.117168. Epub 2010 Apr 7.
Research suggests that anthocyanins from berry fruit may affect a variety of physiological responses, including endothelial function, but little information is available regarding the pharmacokinetics of these flavonoids in humans. To determine the pharmacokinetics of cranberry anthocyanins, a study was undertaken in 15 participants (age: 62 +/- 8 y) with coronary artery disease. Blood and urine samples were collected between baseline (0 h) and 4 h after consumption of 480 mL cranberry juice (54% juice; 835 mg total polyphenols; 94.47 mg anthocyanins). Marked inter-individual differences in plasma anthocyanin pharmacokinetics were observed with maximum anthocyanin concentrations detected between 1 and 3 h. Cranberry anthocyanins were bioavailable but with notable differences in the maximum concentration and area under the curve(0-4h) between individual participants. The pattern of anthocyanin glucosides observed in plasma and urine generally reflected the relative concentration determined in the juice. Plasma concentrations of the individual anthocyanins ranged between 0.56 and 4.64 nmol/L. Total recovery of urinary anthocyanin was 0.79 +/- 0.90% of the dose delivered. These data are in agreement with the pharmacokinetics of anthocyanins from other foods suggesting that cranberry anthocyanins are poorly absorbed and rapidly removed from plasma. Observed concentrations of plasma anthocyanins appear insufficient to alter radical load or redox potential but may be adequate to affect signal transduction and/or gene expression.
研究表明，浆果中的花色苷可能影响多种生理反应，包括内皮功能，但关于这些类黄酮在人体内的药代动力学信息却很少。为了确定蔓越莓花色苷的药代动力学，一项针对 15 名患有冠状动脉疾病的参与者（年龄：62 ± 8 岁）的研究进行了。在饮用 480 毫升蔓越莓汁（54%果汁；总多酚 835 毫克；花色苷 94.47 毫克）后，在基线（0 小时）和 4 小时之间收集血液和尿液样本。观察到个体间血浆花色苷药代动力学存在显著差异，最大花色苷浓度在 1 至 3 小时之间检测到。蔓越莓花色苷是生物可利用的，但个体间最大浓度和曲线下面积（0-4 小时）存在显著差异。在血浆和尿液中观察到的花色苷糖苷的模式通常反映了果汁中相对浓度。血浆中单个花色苷的浓度范围在 0.56 至 4.64nmol/L 之间。尿中花色苷的总回收率为剂量的 0.79 ± 0.90%。这些数据与其他食物中花色苷的药代动力学一致，表明蔓越莓花色苷吸收不良，且从血浆中迅速清除。观察到的血浆花色苷浓度似乎不足以改变自由基负荷或氧化还原电位，但可能足以影响信号转导和/或基因表达。
