Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, China.
Nutrients. 2024 Mar 9;16(6):782. doi: 10.3390/nu16060782.
This study aims to update the evidence and clarify whether cranberry possesses lipid-lowering and hypoglycemic properties in humans. PubMed, Web of Science, and Scopus were searched to identify relevant articles published up to December 2023. In total, 3145 publications were reviewed and 16 of them were included for qualitative synthesis and meta-analysis. Stata 15.0 and Review Manager 5.4 were applied for statistical analyses. The results revealed a significant decrease in the total cholesterol to high-density lipoprotein cholesterol ratio (TC/HDL-C) (MD = -0.24; 95% CI: -0.45, -0.04; = 0.02) and homeostasis model assessment of insulin resistance (HOMA-IR) (MD = -0.59; 95% CI: -1.05, -0.14; = 0.01) with cranberry consumption. However, it did not influence total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), fasting blood glucose (FBG), glycated hemoglobin (HbA1c), and fasting insulin. In subgroup analysis, cranberry consumption in dried form (capsules, powder, and tablets) was found to significantly decrease the fasting insulin level (three studies, one hundred sixty-five participants, MD = -2.16; 95% CI: -4.24, -0.07; = 0.04), while intervention duration, health conditions, and dosage of polyphenols and anthocyanins had no impact on blood lipid and glycemic parameters. In summary, cranberry might have potential benefits in regulating lipid and glucose profiles.
本研究旨在更新证据并阐明蔓越莓是否具有降低血脂和降血糖的人体功效。通过检索 PubMed、Web of Science 和 Scopus，共检索到截至 2023 年 12 月的相关文献 3145 篇，并对其中 16 篇进行定性综合和荟萃分析。采用 Stata 15.0 和 Review Manager 5.4 进行统计分析。结果显示，蔓越莓的摄入可显著降低总胆固醇与高密度脂蛋白胆固醇比值（TC/HDL-C）（MD = -0.24；95%CI：-0.45，-0.04； = 0.02）和稳态模型评估的胰岛素抵抗指数（HOMA-IR）（MD = -0.59；95%CI：-1.05，-0.14； = 0.01）。但蔓越莓的摄入并不影响总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、三酰甘油（TG）、空腹血糖（FBG）、糖化血红蛋白（HbA1c）和空腹胰岛素。亚组分析显示，蔓越莓干制品（胶囊、粉末和片剂）的摄入可显著降低空腹胰岛素水平（三项研究，165 名参与者，MD = -2.16；95%CI：-4.24，-0.07； = 0.04），而干预持续时间、健康状况以及多酚和花青素的剂量对血脂和血糖参数无影响。总之，蔓越莓可能在调节血脂和血糖谱方面具有潜在益处。
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