Department of Microbiology and Immunology, Queen's University, Kingston, Ontario, Canada.
AIDS. 2010 Jun 1;24(9):1371-4. doi: 10.1097/QAD.0b013e3283391d2b.
A newly described cytokine, interleukin-27 (IL-27), that activates naive CD4 T cells, has recently been shown to be an anti-HIV cytokine. However, the effect of HIV infection on IL-27 expression has not been characterized. We found that clinical characteristics, including HIV viral load, hepatitis C virus coinfection, and CD4 T cell counts, were associated with changes in serum IL-27. Overall, our results suggest circulating HIV may suppress IL-27, a critical concept in treatment development with this cytokine.
一种新描述的细胞因子白细胞介素-27（IL-27），能够激活初始 CD4 T 细胞，最近被证明是一种抗 HIV 的细胞因子。然而，HIV 感染对 IL-27 表达的影响尚未得到描述。我们发现，临床特征，包括 HIV 病毒载量、丙型肝炎病毒合并感染和 CD4 T 细胞计数，与血清 IL-27 的变化有关。总的来说，我们的结果表明，循环 HIV 可能抑制 IL-27，这是该细胞因子治疗开发中的一个关键概念。
