细菌感染模型的光学成像
Optical Imaging of Bacterial Infection Models.
作者信息
Leevy W Matthew, Serazin Nathan, Smith Bradley D
机构信息
Department of Chemistry and Biochemistry, 251 Nieuwland Science Hall, University of Notre Dame, Notre Dame, IN 46556, USA.
出版信息
Drug Discov Today Dis Models. 2007 Fall;4(3):91-97. doi: 10.1016/j.ddmod.2007.07.001.
Abstract
Over the last thirteen years, the field of optical imaging has expanded from in vitro fluorescence microscopy of cells to in vivo imaging of living animals. Recent advances in optical imaging of bacterial infection have been propelled by the invention of genetic methods that produce fluorescent and bioluminescent bacteria, and also the discovery of synthetic fluorescent probes that selectively target bacterial cell surfaces. Optical imaging is an effective method of conducting longitudinal studies of bacterial infection in small animals such as nude mice. It can be used to address questions in medical microbiology concerning migration and colonization and it is an attractive method for determining the efficacy of antibiotic therapies.
摘要
在过去的十三年里，光学成像领域已从细胞的体外荧光显微镜检查扩展到活体动物的体内成像。产生荧光和生物发光细菌的基因方法的发明以及选择性靶向细菌细胞表面的合成荧光探针的发现推动了细菌感染光学成像的最新进展。光学成像是对裸鼠等小动物的细菌感染进行纵向研究的有效方法。它可用于解决医学微生物学中有关迁移和定植的问题，并且是确定抗生素治疗效果的一种有吸引力的方法。
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