Suppr超能文献

钙库耗竭导致孕激素诱导的 G 蛋白偶联受体钙信号转导减弱。

Depletion of calcium stores contributes to progesterone-induced attenuation of calcium signaling of G protein-coupled receptors.

机构信息

Institute of Pharmaceutics and Biochemistry, University of Mainz, 55099 Mainz, Germany.

出版信息

Cell Mol Life Sci. 2010 Aug;67(16):2815-24. doi: 10.1007/s00018-010-0360-4. Epub 2010 Apr 8.

Abstract

Progesterone non-genomically attenuates the calcium signaling of the human oxytocin receptor and several other Galpha(q) protein-coupled receptors. High progesterone concentrations are found in the endometrium during pregnancy opposing the responsiveness of the underlying myometrium to labor-inducing hormones. Here, we demonstrate that within minutes, progesterone inhibits oxytocin- and bradykinin-induced contractions of rat uteri, calcium responses induced by platelet-activating factor in the human endometrial cell line MFE-280, and oxytocin-induced calcium signals in PHM1-31 immortalized pregnant human myometrial cells. Using human embryonic kidney (HEK293) cells as model system, we analyzed the molecular mechanisms underlying these effects. Our data indicate that progesterone rapidly depletes intracellular calcium stores. The resulting desensitization of the cells might contribute to the quiescence of the uterus during pregnancy.

摘要

孕激素非基因组地减弱了人催产素受体和其他几种 Gq 蛋白偶联受体的钙信号。在妊娠期间,子宫内膜中孕激素浓度升高,拮抗了子宫平滑肌对分娩诱导激素的反应性。在这里,我们证明孕激素在几分钟内即可抑制大鼠子宫的催产素和缓激肽诱导的收缩、人子宫内膜细胞系 MFE-280 中血小板激活因子诱导的钙反应,以及 PHM1-31 永生化妊娠人子宫平滑肌细胞中的催产素诱导的钙信号。我们使用人胚肾 (HEK293) 细胞作为模型系统,分析了这些效应的分子机制。我们的数据表明,孕激素迅速耗竭细胞内钙储存。由此产生的细胞脱敏可能有助于妊娠期间子宫的静止。

相似文献

1
Depletion of calcium stores contributes to progesterone-induced attenuation of calcium signaling of G protein-coupled receptors.
Cell Mol Life Sci. 2010 Aug;67(16):2815-24. doi: 10.1007/s00018-010-0360-4. Epub 2010 Apr 8.
3
Conflicting Nongenomic Effects of Progesterone in the Myometrium of Pregnant Rats.
Int J Mol Sci. 2021 Feb 22;22(4):2154. doi: 10.3390/ijms22042154.
8

引用本文的文献

2
Downregulation of kinin B1 receptor function by B2 receptor heterodimerization and signaling.
Cell Signal. 2015 Jan;27(1):90-103. doi: 10.1016/j.cellsig.2014.09.019. Epub 2014 Oct 5.
3
TRPC1, STIM1, and ORAI influence signal-regulated intracellular and endoplasmic reticulum calcium dynamics in human myometrial cells.
Biol Reprod. 2011 Aug;85(2):315-26. doi: 10.1095/biolreprod.111.091082. Epub 2011 May 12.

本文引用的文献

1
Progesterone, but not 17-alpha-hydroxyprogesterone caproate, inhibits human myometrial contractions.
Am J Obstet Gynecol. 2008 Oct;199(4):391.e1-7. doi: 10.1016/j.ajog.2008.06.085.
2
Candidates for membrane progestin receptors--past approaches and future challenges.
Comp Biochem Physiol C Toxicol Pharmacol. 2008 Nov;148(4):381-9. doi: 10.1016/j.cbpc.2008.05.019. Epub 2008 Jun 15.
4
A modification of the method of Dale and Laidlaw for standardization of posterior pituitary extract.
Br J Pharmacol Chemother. 1948 Dec;3(4):328-34. doi: 10.1111/j.1476-5381.1948.tb00396.x.
5
Steroid hormone control of myometrial contractility and parturition.
Semin Cell Dev Biol. 2007 Jun;18(3):321-31. doi: 10.1016/j.semcdb.2007.05.003. Epub 2007 May 18.
10
Calcium signalling in smooth muscle.
Cell Calcium. 2005 Sep-Oct;38(3-4):397-407. doi: 10.1016/j.ceca.2005.06.018.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验