Valet M, Sprenger T, Tölle T R
Neurologische Klinik und Poliklinik, Technische Universität München, Klinikum rechts der Isar, Ismaninger Str. 22, 81675, München, Deutschland.
Schmerz. 2010 Apr;24(2):114-21. doi: 10.1007/s00482-010-0896-0.
Functional neuroimaging methods such as positron emission tomography (PET) or functional magnetic resonance imaging (fMRI) provide fascinating insights into the cerebral processing of pain. Neuroimaging studies have shown that no clearly defined "pain centre" exists. Rather, an entire network of brain regions is involved in the processing of nociceptive information, which leads to the subjective impression of "pain". Sophisticated study designs nowadays permit the characterisation of different components of pain processing. In this review, we summarise neuroimaging studies, which contributed to the characterisation of these different aspects of cerebral pain processing, such as somatosensory (discrimination of different stimulus modalities, noxious vs non-noxious, summation), emotional, cognitive (attention, anticipation, distraction), vegetative (homeostasis) and motor aspects.
正电子发射断层扫描（PET）或功能磁共振成像（fMRI）等功能神经成像方法为大脑对疼痛的处理提供了引人入胜的见解。神经成像研究表明，不存在明确界定的“疼痛中枢”。相反，整个脑区网络参与伤害性信息的处理，这导致了“疼痛”的主观感受。如今，精密的研究设计能够对疼痛处理的不同组成部分进行特征描述。在本综述中，我们总结了神经成像研究，这些研究有助于对大脑疼痛处理的这些不同方面进行特征描述，例如躯体感觉（区分不同刺激模式、有害与无害、总和）、情感、认知（注意力、预期、分心）、自主（内稳态）和运动方面。
