Department of Laboratory Medicine and Pathology, Analytical and Environmental Toxicology Division, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada T6G 2G3.
Environ Sci Technol. 2010 May 15;44(10):3986-91. doi: 10.1021/es100128n.
Children may be exposed to arsenic during contact with structures treated with chromated copper arsenate (CCA). A high frequency of hand-to-mouth activity may increase their risk of ingesting arsenic. Previous work showed that arsenic concentrations in the hand-wash samples of children playing on CCA playgrounds were four times higher than those playing on non-CCA playgrounds. It is not clear whether playing on CCA playgrounds results in elevated overall exposure to arsenic. The objective of this study was to perform arsenic biomonitoring in children to determine whether playing on CCA-treated playgrounds substantially contributes to their overall exposure to arsenic. One hundred and twenty five saliva samples from 61 children and 101 urine samples from 45 children were collected after children played on 8 CCA and 8 non-CCA playgrounds. Arsenic speciation analysis was conducted using high performance liquid chromatography combined with inductively coupled plasma mass spectrometry. The arsenic species detected in the urine and saliva samples from children playing on CCA and non-CCA playgrounds were similar. Dimethylarsinic acid and arsenobetaine were the main arsenic species found in urine samples. The sum of inorganic trivalent and pentavalent arsenic, monomethylarsonic acid, and dimethylarsinic acid in urine was 15 +/- 28 microg/L in the CCA group and 12 +/- 23 microg/L in the non-CCA group (p = 0.60). The sum of these species in saliva was 1.1 +/- 2.1 microg/L in the CCA group and 1.4 +/- 1.1 microg/L in the non-CCA group (p = 0.32). These results show that there is no significant difference in the concentration or speciation of arsenic between the samples from children playing on CCA and non-CCA playgrounds. Contact with CCA playgrounds is not likely to significantly contribute to the overall arsenic exposure in children; other sources such as dietary arsenic may be a main contributor to their overall exposure.
儿童在接触使用铬酸铜砷酸盐（CCA）处理过的结构物时可能会接触到砷。频繁的手口活动可能会增加他们摄入砷的风险。以前的研究表明，在 CCA 游乐场玩耍的儿童洗手样本中的砷浓度比在非 CCA 游乐场玩耍的儿童高四倍。目前尚不清楚在 CCA 游乐场玩耍是否会导致砷的总体暴露水平升高。本研究的目的是对儿童进行砷生物监测，以确定在 CCA 处理过的游乐场玩耍是否会显著增加他们对砷的总体暴露。在儿童在 8 个 CCA 和 8 个非 CCA 游乐场玩耍后，收集了 61 名儿童的 125 份唾液样本和 45 名儿童的 101 份尿液样本。使用高效液相色谱-电感耦合等离子体质谱联用技术进行砷形态分析。在 CCA 和非 CCA 游乐场玩耍的儿童的尿液和唾液样本中检测到的砷形态相似。二甲基砷酸和砷甜菜碱是尿液样本中主要的砷形态。尿液中无机三价和五价砷、一甲基砷酸和二甲基砷酸的总和在 CCA 组中为 15 ± 28 μg/L，在非 CCA 组中为 12 ± 23 μg/L（p = 0.60）。这些物质在唾液中的总和在 CCA 组中为 1.1 ± 2.1 μg/L，在非 CCA 组中为 1.4 ± 1.1 μg/L（p = 0.32）。这些结果表明，CCA 和非 CCA 游乐场玩耍的儿童样本中砷的浓度或形态没有显著差异。接触 CCA 游乐场不太可能显著增加儿童的砷总体暴露；饮食中的砷等其他来源可能是他们总体暴露的主要来源。
