5,7-二甲氧基邻苯二甲酸酐与远程功能化的碘化烷基的选择性偶联反应：幽门螺杆菌抗生素的简便外消旋合成。
Chemoselective coupling reactions of 5,7-dimethoxyphthalide with the remotely functionalized alkyl iodides: facile racemic synthesis of Helicobacter pylori antibiotics.
机构信息
Division of Organic Chemistry, National Chemical Laboratory (CSIR), Pune 411 008, India.
出版信息
J Org Chem. 2010 May 7;75(9):3121-4. doi: 10.1021/jo100168f.
PMID:20377262
Abstract
Highly chemoselective coupling reactions of 5,7-dimethoxyphthalide carbanion with the remotely functionalized long chain alkyl iodides have been demonstrated to accomplish the concise and efficient synthesis of Helicobacter pylori antibiotics, the CJ-molecules, and sporotricale methyl ether.
摘要
已经证明，5,7-二甲氧基邻苯二甲酸酐碳负离子与远程功能化长链烷基碘化物的高化学选择性偶联反应可以完成幽门螺杆菌抗生素 CJ 分子和sporotrichal 甲基醚的简洁高效合成。
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