Awasthi Amardeep, Singh Mandeep, Rathee Garima, Chandra Ramesh
Drug Discovery and Development Laboratory, Department of Chemistry, University of Delhi Delhi-110007 India
Dr. B. R. Ambedkar Center for Biomedical Research, University of Delhi Delhi-110007 India.
RSC Adv. 2020 Mar 27;10(21):12626-12652. doi: 10.1039/d0ra00701c. eCollection 2020 Mar 24.
We have provided a critical review that focuses on key developments in the area of 3-substituted phthalides and their role in the development of important biologically active natural products. 3-Substituted phthalides are vital molecules owing to their fascinating biological activity. The scope, isolation, and characterization of various naturally occurring racemic and chiral 3-substituted phthalides have been covered. We have put significant emphasis on recently developed research methodologies for the synthesis of racemic and chiral 3-substituted phthalides. These newer approaches are essential for the development of newer and elegant strategies for the synthesis of phthalide-based or similar molecular architecture with broader substrate scope and higher stereoselectivities. Also, we have discussed the application of 3-substituted phthalides as a precursor for the synthesis of natural products and their analogs.
我们提供了一篇批判性综述，重点关注3-取代苯酞领域的关键进展及其在重要生物活性天然产物开发中的作用。3-取代苯酞因其迷人的生物活性而成为重要分子。文中涵盖了各种天然存在的外消旋和手性3-取代苯酞的范围、分离和表征。我们着重介绍了最近开发的用于合成外消旋和手性3-取代苯酞的研究方法。这些更新的方法对于开发具有更广泛底物范围和更高立体选择性的基于苯酞或类似分子结构的合成新策略至关重要。此外，我们还讨论了3-取代苯酞作为天然产物及其类似物合成前体的应用。
