Chemical Sciences, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA.
Bioorg Med Chem Lett. 2010 May 1;20(9):2809-12. doi: 10.1016/j.bmcl.2010.03.059. Epub 2010 Mar 15.
A series of heterocyclic cycloalkanol ethylamines have been prepared to expand our norepinephrine reuptake inhibitor (NRI) program. Synthesis of a variety of heterocycles identified (+)-S-21, a potent NRI efficacious in an animal model for thermoregulatory dysfunction.
已经制备了一系列杂环环烷醇乙胺，以扩展我们的去甲肾上腺素再摄取抑制剂 (NRI) 计划。各种杂环的合成鉴定了 (+)-S-21，这是一种在体温调节功能障碍动物模型中有效的有效 NRI。
