Department of Medicinal Chemistry, Roche Palo Alto LLC, CA 94304, USA.
Bioorg Med Chem Lett. 2010 Jul 1;20(13):3941-5. doi: 10.1016/j.bmcl.2010.05.008. Epub 2010 May 10.
Recently a class of compounds known as triple reuptake inhibitors has emerged as a new strategy for the treatment of depression. These compounds work by simultaneously inhibiting the synaptic reuptake of serotonin, norepinephrine and dopamine. In this Letter we describe the optimization of a novel series of 2-substituted N-aryl piperazine based triple reuptake inhibitors.
最近，一类被称为三重再摄取抑制剂的化合物作为治疗抑郁症的新策略出现了。这些化合物通过同时抑制血清素、去甲肾上腺素和多巴胺的突触再摄取起作用。在这封信中，我们描述了一系列新型 2-取代 N-芳基哌嗪基三重再摄取抑制剂的优化。
