Bonithon-Kopp C, Raison J, Egloff M, Guy-Grand B, Ducimetière P
Unité de Recherche d'Epidémiologie Cardiovasculaire, INSERM U258, Hôpital Broussais, Paris, France.
J Clin Epidemiol. 1991;44(6):475-82. doi: 10.1016/0895-4356(91)90210-z.
Body mass index (BMI), various anthropometric indices of abdominal fat distribution and some metabolic variables (blood lipids, fasting glucose, blood pressure) were measured in 408 French-born women from an occupational population who volunteered for the study. The aim of the study was to determine the best index for describing the relationships between the body fat pattern and the metabolic risk profile. The four age-adjusted circumference ratios (waist/hip, waist/thigh, xiphoid/hip, xiphoid/thigh) showed similar associations with the metabolic variables whereas the three age-adjusted skinfold ratios (epigastric/thigh, mesogastric/thigh, hypogastric/thigh) tended to be more weakly associated with the metabolic variables, particularly with apolipoprotein (Apo) B and fasting glucose. Multiple regression analyses showed that age-adjusted BMI was significantly related to high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol, Apo A and Apo B, and blood pressure, independently of abdominal fat distribution. After controlling for the effects of BMI, the waist/thigh ratio remained significantly associated to triglyceride, Apo B, fasting glucose, and systolic blood pressure, whereas the waist/hip ratio and the mesogastric/thigh skinfold ratio were significantly related only to triglyceride and systolic blood pressure independently of BMI. With the exception of triglyceride and fasting glucose, the degree of association between the metabolic variables and the abdominal fat distribution tended to be weaker than that observed with the BMI. These results emphasize the importance of the global corpulence in the levels of metabolic variables. However, all indices of abdominal fat distribution were, to varying degrees, independently associated with an unfavorable metabolic profile. Among them, the waist/thigh circumference ratio seems to be a useful indicator of the body fat pattern in women.
对408名来自职业人群、自愿参与该研究的法国出生女性，测量了她们的体重指数（BMI）、腹部脂肪分布的各种人体测量指标以及一些代谢变量（血脂、空腹血糖、血压）。该研究的目的是确定描述体脂模式与代谢风险状况之间关系的最佳指标。四个年龄调整后的周长比（腰/臀、腰/大腿、剑突/臀、剑突/大腿）与代谢变量显示出相似的关联，而三个年龄调整后的皮褶比（上腹部/大腿、中腹部/大腿、下腹部/大腿）与代谢变量的关联往往较弱，尤其是与载脂蛋白（Apo）B和空腹血糖。多元回归分析表明，年龄调整后的BMI与高密度脂蛋白（HDL）胆固醇、低密度脂蛋白（LDL）胆固醇、Apo A和Apo B以及血压显著相关，与腹部脂肪分布无关。在控制BMI的影响后，腰/大腿比仍与甘油三酯、Apo B、空腹血糖和收缩压显著相关，而腰/臀比和中腹部/大腿皮褶比仅与甘油三酯和收缩压显著相关，与BMI无关。除甘油三酯和空腹血糖外，代谢变量与腹部脂肪分布之间的关联程度往往比BMI观察到的要弱。这些结果强调了总体肥胖在代谢变量水平中的重要性。然而，腹部脂肪分布的所有指标在不同程度上都与不良代谢状况独立相关。其中，腰/大腿周长比似乎是女性体脂模式的一个有用指标。
