• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Molecular and alternative methods for diagnosis of acute myeloid leukemia with mutated NPM1: flexibility may help.

作者信息

Falini Brunangelo, Martelli Maria Paola, Pileri Stefano A, Mecucci Cristina

出版信息

Haematologica. 2010 Apr;95(4):529-34. doi: 10.3324/haematol.2009.017822.

DOI:10.3324/haematol.2009.017822
PMID:20378574
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2857180/
Abstract
摘要

相似文献

1
Molecular and alternative methods for diagnosis of acute myeloid leukemia with mutated NPM1: flexibility may help.用于诊断伴有NPM1突变的急性髓系白血病的分子及替代方法：灵活性可能有所帮助。
Haematologica. 2010 Apr;95(4):529-34. doi: 10.3324/haematol.2009.017822.
2
Acute myeloid leukemia with mutated NPM1 demonstrating multilineage dysplasia and marked thrombocytosis.伴有NPM1突变、表现为多系发育异常和显著血小板增多的急性髓系白血病。
Br J Haematol. 2017 Aug;178(3):350. doi: 10.1111/bjh.14741. Epub 2017 Jul 5.
3
Acute myeloid leukemia with NPM1 and FLT3 ITD mimicking acute promyelocytic leukemia.伴有NPM1和FLT3内部串联重复突变的急性髓系白血病，酷似急性早幼粒细胞白血病。
Blood. 2020 Sep 17;136(12):1467. doi: 10.1182/blood.2020007198.
4
Acute myeloid leukemia with mutated nucleophosmin (NPM1): is it a distinct entity?伴有核仁磷酸蛋白（NPM1）突变的急性髓系白血病：它是一个独特的实体吗？
Blood. 2011 Jan 27;117(4):1109-20. doi: 10.1182/blood-2010-08-299990. Epub 2010 Oct 28.
5
Development of a flow cytometric method to detect the presence of mutated nucleophosmin 1 in acute myeloid leukemia.一种用于检测急性髓系白血病中突变型核磷蛋白1存在的流式细胞术方法的开发。
Hematol Oncol Stem Cell Ther. 2015 Sep;8(3):106-14. doi: 10.1016/j.hemonc.2015.06.009. Epub 2015 Jul 9.
6
Minimal/Measurable Residual Disease Monitoring in -Mutated Acute Myeloid Leukemia: A Clinical Viewpoint and Perspectives.伴有突变的急性髓系白血病中的微小残留病监测：临床观点和展望。
Int J Mol Sci. 2018 Nov 6;19(11):3492. doi: 10.3390/ijms19113492.
7
Rare coincident NPM1 and RUNX1 mutations in intermediate risk acute myeloid leukemia display similar patterns to single mutated cases.中危急性髓系白血病中罕见的NPM1和RUNX1基因同时突变表现出与单基因突变病例相似的模式。
Haematologica. 2014 Feb;99(2):e20-1. doi: 10.3324/haematol.2013.099754.
8
Acute myeloid leukemia with mutated nucleophosmin (NPM1): molecular, pathological, and clinical features.伴有核磷蛋白（NPM1）突变的急性髓系白血病：分子、病理及临床特征
Cancer Treat Res. 2010;145:149-68. doi: 10.1007/978-0-387-69259-3_9.
9
A one-mutation mathematical model can explain the age incidence of acute myeloid leukemia with mutated nucleophosmin (NPM1).一个单突变数学模型可以解释伴有核磷蛋白（NPM1）突变的急性髓系白血病的年龄发病率。
Haematologica. 2008 Aug;93(8):1219-26. doi: 10.3324/haematol.13209. Epub 2008 Jul 4.
10
Reply to "rare coincident NPM1 and RUNX1 mutations in intermediate risk acute myeloid leukemia display similar patterns to single mutated cases". Haematologica 2014;99(2):e20-21.对《中危急性髓系白血病中罕见的NPM1和RUNX1基因同时突变与单基因突变病例表现出相似模式》的回复。《血液学杂志》2014年；99(2):e20 - 21。
Haematologica. 2014 Feb;99(2):e22. doi: 10.3324/haematol.2013.100669.

引用本文的文献

1
A Comprehensive Genomic Analysis of Nucleophosmin (NPM1) in Acute Myeloid Leukemia.急性髓系白血病中核磷蛋白（NPM1）的综合基因组分析
Cancers (Basel). 2025 Aug 20;17(16):2710. doi: 10.3390/cancers17162710.
2
Criteria for Diagnosis and Molecular Monitoring of NPM1-Mutated AML.NPM1 突变型 AML 的诊断和分子监测标准。
Blood Cancer Discov. 2024 Jan 8;5(1):8-20. doi: 10.1158/2643-3230.BCD-23-0144.
3
Baseline immunophenotypic profile of bone marrow leukemia cells in acute myeloid leukemia with nucleophosmin-1 gene mutation: a EuroFlow study.伴核仁磷酸蛋白-1基因突变的急性髓系白血病骨髓白血病细胞的基线免疫表型特征：一项欧洲流式细胞术研究
Blood Cancer J. 2023 Sep 4;13(1):132. doi: 10.1038/s41408-023-00909-4.
4
Development of E-ice-COLD-PCR assay combined with HRM analysis for Nucleophosmin1 gene mutation detection in acute myelogenous leukemia.E-ice-COLD-PCR 联合 HRM 分析检测急性髓系白血病核仁磷酸蛋白基因突变
PLoS One. 2022 Sep 14;17(9):e0274034. doi: 10.1371/journal.pone.0274034. eCollection 2022.
5
Reverse Electrochemical Sensing of FLT3-ITD Mutations in Acute Myeloid Leukemia Using Gold Sputtered ZnO-Nanorod Configured DNA Biosensors.利用金溅射 ZnO 纳米棒结构 DNA 生物传感器反向电化学检测急性髓系白血病中的 FLT3-ITD 突变。
Biosensors (Basel). 2022 Mar 10;12(3):170. doi: 10.3390/bios12030170.
6
A Curious Novel Combination of () Gene Mutations Leading to Aberrant Cytoplasmic Dislocation of in Acute Myeloid Leukemia (AML).急性髓系白血病（AML）中导致异常细胞质移位的（）基因突变的奇特组合。
Genes (Basel). 2021 Sep 16;12(9):1426. doi: 10.3390/genes12091426.
7
-Mutated Myeloid Neoplasms with <20% Blasts: A Really Distinct Clinico-Pathologic Entity?伴有<20%原始细胞的骨髓增生异常肿瘤：一种真正独特的临床病理实体？
Int J Mol Sci. 2020 Nov 26;21(23):8975. doi: 10.3390/ijms21238975.
8
Nucleophosmin1 (NPM1) abnormality in hematologic malignancies, and therapeutic targeting of mutant NPM1 in acute myeloid leukemia.血液系统恶性肿瘤中的核磷蛋白1（NPM1）异常以及急性髓系白血病中突变型NPM1的治疗靶点
Ther Adv Hematol. 2020 Feb 3;11:2040620719899818. doi: 10.1177/2040620719899818. eCollection 2020.
9
A novel type of mutation characterized by multiple internal tandem repeats in a case of cytogenetically normal acute myeloid leukemia.在一例细胞遗传学正常的急性髓系白血病中，一种以多个内部串联重复为特征的新型突变。
Haematologica. 2018 Dec;103(12):e575-e577. doi: 10.3324/haematol.2018.190959. Epub 2018 Jun 14.
10
Mutation Analysis in Acute Myeloid Leukemia: Comparison of Three Techniques - Sanger Sequencing, Pyrosequencing, and Real-Time Polymerase Chain Reaction.急性髓系白血病的突变分析：三种技术的比较——桑格测序、焦磷酸测序和实时聚合酶链反应
Turk J Haematol. 2018 Mar 1;35(1):49-53. doi: 10.4274/tjh.2017.0095. Epub 2017 Nov 13.

本文引用的文献

1
Favorable prognostic impact of NPM1 mutations in older patients with cytogenetically normal de novo acute myeloid leukemia and associated gene- and microRNA-expression signatures: a Cancer and Leukemia Group B study.核仁磷酸蛋白 1 突变对细胞遗传学正常的初发急性髓系白血病老年患者具有有利的预后影响及相关的基因和 microRNA 表达特征：一项癌症和白血病组 B 研究。
J Clin Oncol. 2010 Feb 1;28(4):596-604. doi: 10.1200/JCO.2009.25.1496. Epub 2009 Dec 21.
2
Cytoplasmic expression of nucleophosmin accurately predicts mutation in the nucleophosmin gene in patients with acute myeloid leukemia and normal karyotype.细胞质核仁磷酸蛋白表达准确预测核仁磷酸蛋白基因突变在伴有正常核型的急性髓系白血病患者中。
Am J Clin Pathol. 2010 Jan;133(1):34-40. doi: 10.1309/AJCPCI1FFE2DRXIV.
3
Can cytoplasmic nucleophosmin be detected by immunocytochemical staining of cell smears in acute myeloid leukemia?细胞质核仁磷酸蛋白能否通过细胞涂片免疫细胞化学染色在急性髓系白血病中检测到？
Haematologica. 2010 Apr;95(4):670-3. doi: 10.3324/haematol.2009.011817. Epub 2009 Dec 16.
4
Strikingly different molecular relapse kinetics in NPM1c, PML-RARA, RUNX1-RUNX1T1, and CBFB-MYH11 acute myeloid leukemias.在 NPM1c、PML-RARA、RUNX1-RUNX1T1 和 CBFB-MYH11 急性髓系白血病中，分子复发动力学明显不同。
Blood. 2010 Jan 14;115(2):198-205. doi: 10.1182/blood-2009-04-212530. Epub 2009 Nov 9.
5
Cytoplasmic localization of nucleophosmin in bone marrow blasts of acute myeloid leukemia patients is not completely concordant with NPM1 mutation and is not predictive of prognosis.急性髓系白血病患者骨髓母细胞中核磷蛋白的细胞质定位与NPM1突变并不完全一致，且不能预测预后。
Cancer. 2009 Oct 15;115(20):4737-44. doi: 10.1002/cncr.24543.
6
Minimal residual disease levels assessed by NPM1 mutation-specific RQ-PCR provide important prognostic information in AML.通过NPM1突变特异性RQ-PCR评估的微小残留病水平为急性髓系白血病提供了重要的预后信息。
Blood. 2009 Sep 10;114(11):2220-31. doi: 10.1182/blood-2009-03-213389. Epub 2009 Jul 8.
7
Nucleophosmin (NPM1) mutations in adult and childhood acute myeloid leukaemia: towards definition of a new leukaemia entity.成人和儿童急性髓系白血病中的核磷蛋白（NPM1）突变：迈向新白血病实体的定义
Hematol Oncol. 2009 Dec;27(4):171-81. doi: 10.1002/hon.904.
8
Altered nucleophosmin transport in acute myeloid leukaemia with mutated NPM1: molecular basis and clinical implications.NPM1突变的急性髓系白血病中核磷蛋白转运改变：分子基础及临床意义
Leukemia. 2009 Oct;23(10):1731-43. doi: 10.1038/leu.2009.124. Epub 2009 Jun 11.
9
Detection of nucleophosmin gene mutations in plasma from patients with acute myeloid leukemia: clinical significance and implications.急性髓系白血病患者血浆中核磷蛋白基因突变的检测：临床意义及启示
Cancer Biomark. 2009;5(1):51-8. doi: 10.3233/CBM-2009-0583.
10
Quantitative monitoring of NPM1 mutations provides a valid minimal residual disease parameter following allogeneic stem cell transplantation.对NPM1突变进行定量监测可为异基因干细胞移植后的微小残留病提供有效的参数。
Exp Hematol. 2009 Jan;37(1):135-42. doi: 10.1016/j.exphem.2008.09.014.