Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University, Seoul, Korea.
J Gynecol Oncol. 2010 Mar;21(1):56-8. doi: 10.3802/jgo.2010.21.1.56. Epub 2010 Mar 31.
Ovarian stromal tumors containing Leydig cell components are rare. Only a few cases of ovarian stromal Leydig cell tumors characterized by clusters of Leydig cells have been reported to date. Here, we present the first case report of a 65-year-old woman with a cellular fibroma of the ovary containing Leydig cell hyperplasia. Microscopic examination revealed the proliferation of spindle cells arranged in intersecting bundles with mild nuclear atypia and an average of 2-3 mitotic figures per ten high-power fields. Multifocal nests of polygonal cells with abundant eosinophilic cytoplasm and round nuclei were seen within the spindle cells. Final pathology of the tumor revealed a cellular fibroma including Leydig cell hyperplasia.
卵巢含有睾丸间质细胞成分的间质肿瘤较为罕见。迄今为止，仅有少数几例以成群睾丸间质细胞为特征的卵巢间质睾丸间质细胞瘤的病例报告。在此，我们首次报道了一例 65 岁女性卵巢纤维瘤伴睾丸间质细胞增生的病例。镜下观察显示，梭形细胞呈交叉束状排列，细胞核轻度异型，每 10 个高倍视野有 2-3 个有丝分裂象。梭形细胞内可见多灶性多边形细胞巢，胞质丰富嗜酸性，细胞核圆形。肿瘤的最终病理显示为包含睾丸间质细胞增生的纤维细胞瘤。
