Wu H, Xie J, Huang W, Wu J
Eur J Gynaecol Oncol. 2014;35(1):81-3.
Mitotically active cellular fibroma (MACF) is characterized by increased cellularity, mitotic activity, and less frequently, nuclear atypia, which comprises 10% of ovarian fibromatous tumors. The authors report the case of a 76-year-old woman who presented at the present hospital with a two-month pelvic mass. B ultrasound disclosed a 75 x 52 x 41 mm mass in the right accessories. A hysterectomy and bilateral salpingo-oophorectomy was performed. Histologically, the tumor was composed of a densely cellular proliferation of fibrolastic-like cells with bland nuclear features and arranged in a fascicular pattern. There were more than four mitotic figures per ten high-power fields (HPFs). The histological diagnosis for the mass of the right ovary was MACF. MACF should be distinguished from ovarian fibrosarcoma. MACF is a recent histopathologic entity. Despite the high count of mitotic figures, the clinical course of the tumor is typically uneventful. Long-term clinical follow-up is recommended.
有丝分裂活跃的细胞性纤维瘤（MACF）的特征是细胞增多、有丝分裂活性增加，较少见的是核异型性，其占卵巢纤维瘤性肿瘤的10%。作者报告了一例76岁女性患者，因盆腔肿物两个月前来本院就诊。B超显示右侧附件区有一个75×52×41mm的肿物。进行了子宫切除术和双侧输卵管卵巢切除术。组织学上，肿瘤由纤维母细胞样细胞密集增殖构成，核形态温和，呈束状排列。每十个高倍视野（HPF）中有超过四个有丝分裂象。右侧卵巢肿物的组织学诊断为MACF。MACF应与卵巢纤维肉瘤相鉴别。MACF是一种新的组织病理学实体。尽管有丝分裂象计数较高，但该肿瘤的临床过程通常平稳。建议进行长期临床随访。
