Department of Ophthalmology, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390-9057, USA.
Graefes Arch Clin Exp Ophthalmol. 2010 Oct;248(10):1519-21. doi: 10.1007/s00417-010-1366-1. Epub 2010 Apr 9.
To compare intraocular vascular endothelial growth factor (VEGF) level in patients with and without Coats' disease, and to report a case of Coats' disease that responded to intravitreal injection of bevacizumab.
Intraocular fluid was obtained from four eyes with Coats' disease (subretinal fluid in three eyes and aqueous in one eye) and from five eyes with rhegmatogenous retinal detachment (subretinal fluid in four eyes and vitreous in one eye). Intraocular VEGF level was compared between these two groups. In one eye with stage 2B Coats' disease, macular edema, visual acuity, and intraocular VEGF level were compared before and after intravitreal injection of bevacizumab.
Mean intraocular VEGF level in eyes with Coats' disease was 2,394.5 pg/ml, compared to 15.3 pg/ml in eyes with rhegmagenous retinal detachment. In the eye with stage 2B Coats' disease, macular edema was reduced after bevacizumab injection, and the visual acuity improved from 0.05 to 0.2. Intraocular VEGF level decreased from 1247 pg/ml to 20.4 pg/ml 1 month after the injection.
Coats' disease is associated with increased intraocular VEGF level. Bevacizumab may be a valuable adjunctive treatment for Coats' disease.
比较 Coats 病患者和非 Coats 病患者的眼内血管内皮生长因子（VEGF）水平，并报告一例对贝伐单抗玻璃体腔内注射有反应的 Coats 病病例。
从四例 Coats 病患者（三例为视网膜下积液，一例为眼内液）的四只眼和五例孔源性视网膜脱离患者（四只眼为视网膜下积液，一只眼为玻璃体）中获得眼内液。比较两组间的眼内 VEGF 水平。对一例 2B 期 Coats 病合并黄斑水肿的患者，比较贝伐单抗玻璃体腔内注射前后的黄斑水肿、视力和眼内 VEGF 水平。
Coats 病眼的平均眼内 VEGF 水平为 2394.5pg/ml，而孔源性视网膜脱离眼为 15.3pg/ml。在 2B 期 Coats 病眼中，黄斑水肿在贝伐单抗注射后减轻，视力从 0.05 提高到 0.2。眼内 VEGF 水平在注射后 1 个月从 1247pg/ml 降至 20.4pg/ml。
Coats 病与眼内 VEGF 水平升高有关。贝伐单抗可能是 Coats 病的一种有价值的辅助治疗方法。
