科茨病中血管内皮生长因子水平升高：对培加他尼钠的快速反应
Elevated vascular endothelial growth factor levels in Coats disease: rapid response to pegaptanib sodium.
作者信息
Sun Young, Jain Atul, Moshfeghi Darius M
机构信息
Department of Ophthalmology, Stanford University, 300 Pasteur Drive, Room A-157, Stanford, CA 94305, USA.
出版信息
Graefes Arch Clin Exp Ophthalmol. 2007 Sep;245(9):1387-8. doi: 10.1007/s00417-007-0559-8. Epub 2007 Mar 7.
PURPOSE
The purpose was to report a case of elevated intraocular vascular endothelial growth factor (VEGF) levels in a 2-year-old boy with stage 4 Coats disease.
DESIGN
Interventional case report.
METHODS
A 2-year-old boy with severe Coats disease and complex retinal detachment refractory to surgical intervention underwent two injections of intravitreal pegaptanib sodium in his right eye 8 weeks apart.
RESULTS
After intravitreal injection there was a marked reduction in VEGF (908 to 167 pg/ml) levels and improvement of exudation, hemorrhage, and nearly complete reattachment of his retina within 3 weeks of treatment. The patient remains stable 6 months post-treatment.
CONCLUSIONS
Coats disease may have a component of dysregulation of VEGF-mediated angiogenesis as evidenced by elevated levels in this patient.
目的
报告1例4期科茨病2岁男孩眼内血管内皮生长因子（VEGF）水平升高的病例。
设计
介入性病例报告。
方法
一名患有严重科茨病且视网膜脱离复杂、手术干预无效的2岁男孩，右眼相隔8周接受了两次玻璃体内注射培加他尼钠。
结果
玻璃体内注射后，VEGF水平显著降低（从908降至167 pg/ml），渗出、出血情况改善，治疗3周内视网膜几乎完全复位。患者治疗后6个月病情保持稳定。
结论
该患者VEGF水平升高表明，科茨病可能存在VEGF介导的血管生成失调成分。
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